In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

SpanuT.; DeAngelisG.; CiprianiM.; PedruzziB.; DInzeoT.; CataldoM.A.; SgangaG.; TacconelliE.

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In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

机译：耐多药肺炎克雷伯菌和大肠埃希菌在体内出现替加环素耐药性

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Although resistance to tigecycline has been reported in surveillance studies, very few reports have described the emergence of resistance in vivo. We report two cases of patients with infections due to SHV-12-producing Klebsiella pneumoniae and K. pneumoniae carbapenemase-3 (KPC-3)-producing Escherichia coli, which developed tigecycline resistance in vivo after treatment. The reported limited experience underlines the risk of occurrence of a tigecycline MIC increase under treatment pressure.

机译：尽管在监视研究中已经报告了对替加环素的抗药性，但很少有报道描述了体内抗药性的出现。我们报告了两例因产生SHV-12的肺炎克雷伯菌和肺炎克雷伯菌碳青霉烯酶3（KPC-3）产生的大肠杆菌而感染的患者，这些大肠杆菌在治疗后在体内产生了对替加环素的耐药性。报告的有限经验强调在治疗压力下发生替加环素MIC增加的风险。

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《Antimicrobial agents and chemotherapy.》 |2012年第8期|共3页
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SpanuT.; DeAngelisG.; CiprianiM.; PedruzziB.; DInzeoT.; CataldoM.A.; SgangaG.; TacconelliE.;
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1. In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli [J] . SpanuT., DeAngelisG., CiprianiM., Antimicrobial agents and chemotherapy. . 2012,第8期

机译：耐多药肺炎克雷伯菌和大肠埃希菌在体内出现替加环素耐药性
2. Emergence of colistin resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli strains isolated from cancer patients [J] . Mai M. Zafer, Hadir A. El-Mahallawy, Asmaa Abdulhak, Annals of Clinical Microbiology and Antimicrobials . 2019,第1期

机译：从癌症患者中分离的多药抗性Klebsiella肺炎和大肠杆菌菌株的愈合菌抗性的出现
3. The Rapid Emergence of Tigecycline Resistance in bla _KPC–2 Harboring Klebsiella pneumoniae, as Mediated in Vivo by Mutation in tetA During Tigecycline Treatment [J] . Xiaoxing Du, Fang He, Qiucheng Shi, Frontiers in Microbiology . 2018,第6期

机译：<斜斜体> BLA <亚kPC-2 窝藏<斜视> klebsiella肺炎，如介导的<斜体>静脉曲张，静脉曲张<斜视> TETA 在TIGECOLINE治疗期间
4. Optimization of expression conditions of dhaT gene from Klebsiella pneumoniae in Escherichia coli using uniform design [C] . China-Japan-Korea Joint Symposium on Enzyme Engineering . 2004

机译：均匀设计法优化肺炎克雷伯菌dhaT基因在大肠杆菌中的表达条件。
5. Lipopolysaccharide inner core oligosaccharide biosynthesis and outer membrane stability in Escherichia coli and Klebsiella pneumoniae. [D] . Frirdich, Emilisa. 2005

机译：脂多糖内核寡糖的生物合成和外膜在大肠杆菌和肺炎克雷伯菌中的稳定性。
6. In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli [O] . Teresa Spanu, Giulia De Angelis, Michela Cipriani, 2012

机译：耐多药肺炎克雷伯菌和大肠埃希菌对Tigecycline抗性的体内出现
7. In Vivo Emergence of Tigecycline Resistance in Multidrug-Resistant Klebsiella pneumoniae and Escherichia coli [O] . Spanu, Teresa, De Angelis, Giulia, Cipriani, Maria Celeste, 2012

机译：耐多药肺炎克雷伯菌和大肠埃希菌对Tigecycline抗性的体内出现

In vivo emergence of tigecycline resistance in multidrug-resistant Klebsiella pneumoniae and Escherichia coli

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