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Design and validation of two optical beacons for guidewire localization in breast-conserving surgery

机译：用于保乳手术中导丝定位的两个光学信标的设计和验证

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摘要

Stereotactically placed guidewires are used for indicating the location of a nonpalpable carcinoma in breast-conserving surgery. Pathologists use the end of the embedded guidewire to guide sectioning during intraoperative margin assessment, but they do not currently have a tool to indicate the location of the guidewire end for informed sectioning. We present analysis and experimental testing of two optical methods for localizing the end of an embedded fiber-optic guidewire: the first uses irradiance emitted from the fiber to indicate the location of the guidewire end, while the second system uses the fiber optic to create a photoacoustic pulse for localization. Both systems locate the end of the guidewire within ±5 mm, which ensures that the lesion of interest is bisected during sectioning. The accuracy of the irradiance-based beacon is influenced by standard margin paints, so the photoacoustic beacon proved more useful under current tissue-handling protocols.
机译：立体定向放置的导丝用于指示在保留乳房的手术中不可触及的癌的位置。病理学家在术中切缘评估期间使用嵌入式导丝的末端来引导切片，但是他们目前没有工具来指示用于知情切片的导丝末端的位置。我们目前对两种用于定位嵌入式光纤导丝末端的光学方法进行分析和实验测试：第一种使用光纤发出的辐照度来指示导丝末端的位置，而第二种系统使用光纤来创建导丝末端。用于定位的光声脉冲。两种系统都将导丝的末端定位在±5毫米内，以确保在切片过程中将目标病变一分为二。基于辐照度的信标的准确性受标准边缘涂料的影响，因此，在当前的组织处理协议下，光声信标被证明更加有用。

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