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首页> 外文期刊>Critical care : >Infectious and immunologic consequences of blood transfusion.
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Infectious and immunologic consequences of blood transfusion.

机译：输血的传染性和免疫性后果。

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Blood transfusions remain common practice in the critical care and surgical settings. Transfusions carry significant risks, including risks for transmission of infectious agents and immune suppression. Transmission of bacterial infections, although rare, is the most common adverse event with transfusion. The risk for transmission of viral infections has decreased over time, clearly because tests are becoming more sensitive in detecting certain viral infections such as hepatitis B, hepatitis C, and HIV. Several immunomodulatory effects are thought to be related to transfusions, and these can result in cancer recurrence, mortality, and postoperative infections. Numerous studies have been performed to examine the role of leukoreduction in decreasing these transfusion-related complications but results remain contradictory. We review the infectious risks associated with blood transfusion and the most recent data on its immunologic effects, specifically on cancer recurrence, mortality, and postoperative infections in surgical patients. We also review the use of leukoreduction in blood transfusion and its role in preventing transfusion-transmitted infections and immunomodulatory complications.
机译：在重症监护和外科手术中输血仍然是普遍的做法。输血具有重大风险，包括传染源传播和免疫抑制的风险。细菌感染的传播虽然很少见，但却是输血最常见的不良事件。病毒感染传播的风险已随着时间的推移而降低，这显然是因为测试在检测某些病毒感染（例如乙型肝炎，丙型肝炎和艾滋病毒）中变得越来越敏感。几种免疫调节作用被认为与输血有关，并且可能导致癌症复发，死亡和术后感染。已经进行了许多研究以检查白细胞减少在减少这些输血相关并发症中的作用，但结果仍然矛盾。我们回顾了与输血有关的感染风险以及有关其免疫学作用的最新数据，尤其是对外科手术患者的癌症复发，死亡率和术后感染的影响。我们还回顾了白细胞减少在输血中的用途及其在预防输血传播的感染和免疫调节并发症中的作用。

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