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首页> 外文期刊>Nanotechnology >Heparinized magnetic mesoporous silica nanoparticles as multifunctional growth factor delivery carriers
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Heparinized magnetic mesoporous silica nanoparticles as multifunctional growth factor delivery carriers

机译：肝素化磁性介孔二氧化硅纳米粒子作为多功能生长因子传递载体

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摘要

Well-defined magnetic mesoporous silica nanoparticles (MMSNs) with a core/shell structure were prepared via a one pot synthesis. Sphere-like magnetite aggregates were obtained as cores of the final nanoparticles by assembly in the presence of polyvinyl pyrrolidone and cetyltrimethylammonium bromide. The nanoparticles have the property of superparamagnetism with a saturation magnetization value of 20.3emug ~1. In addition, the combination of heparin and fluorescence-labeled MMSNs endows the resultant particles (denoted as MFMSNs-HP) with magnetism and fluorescence properties, excellent dispersity in the buffer solutions and cell culture media, anticoagulant activity in the blood stream, and the controlled release of basic fibroblast growth factor (bFGF). Furthermore, the bFGF cell viability assays indicate that MFMSNs-HP has nearly no toxicity to human umbilical vein endothelial cells (HUVEC) up to a concentration of 200μgml ~1, and the proliferation activity of bFGF incorporated into MFMSNs-HP could be retained for at least 6 days. All of these suggest that MFMSNs-HP may serve as a multifunctional carrier for the delivery of growth factors.
机译：通过一锅合成制备了具有核/壳结构的明确定义的磁性介孔二氧化硅纳米粒子（MMSN）。通过在聚乙烯吡咯烷酮和十六烷基三甲基溴化铵的存在下进行组装，获得了球状磁铁矿聚集体作为最终纳米粒子的核。纳米粒子具有超顺磁性的特性，其饱和磁化值为20.3emug〜1。此外，肝素和荧光标记的MMSN的组合赋予所得的颗粒（表示为MFMSNs-HP）具有磁性和荧光特性，在缓冲溶液和细胞培养基中的优异分散性，在血流中的抗凝活性以及受控的释放碱性成纤维细胞生长因子（bFGF）。此外，bFGF细胞生存力分析表明，至200μgml〜1的浓度，MFMSNs-HP对人脐静脉内皮细胞（HUVEC）几乎没有毒性，掺入MFMSNs-HP中的bFGF的增殖活性可保持在200μg/ ml。至少6天。所有这些都表明，MFMSNs-HP可以作为递送生长因子的多功能载体。

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