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EGF-functionalized single-walled carbon nanotubes for targeting delivery of etoposide

机译：EGF功能化的单壁碳纳米管，用于靶向传递依托泊苷

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摘要

To enhance the therapeutic potential of etoposide (ETO), we devised a targeted drug delivery system (TDDS) of epidermal growth factorchitosancarboxyl single-walled carbon nanotubesETO (EGF/CHI/SWNTCOOHs/ETO) using modified SWNTs (m-SWNTs) as the carrier, EGF-functionalized SWNTs (f-SWNTs) as the targeted moiety and ETO as the drug. After SWNTCOOHs were conjugated with CHI (CHI/SWNTCOOHs/ETO), they displayed high solubility and stable dispersion in aqueous solution. The drug loading capacity was approximately 2527%. The m-SWNTs and f-SWNTs had only slight cytotoxicity. ETO was released from EGF/CHI/SWNTCOOHs/ETO at low pH and taken up by tumour cells via adenosine triphosphate (ATP)-dependent endocytosis. The cell death induced by EGF/CHI/SWNTCOOHs/ETO was as much as 2.7 times that due to ETO alone. In summary, these results demonstrated that our TDDS had a greater anticancer effect than free ETO invitro.
机译：为了增强依托泊苷（ETO）的治疗潜力，我们设计了靶向表皮生长因子壳聚糖羧基单壁碳纳米管的药物递送系统（TDDS），使用修饰的SWNT（m-SWNT）作为载体的ETO（EGF / CHI / SWNTCOOHs / ETO） ，EGF功能化的SWNTs（f-SWNTs）作为目标部分，ETO作为药物。将SWNTCOOHs与CHI（CHI / SWNTCOOHs / ETO）共轭后，它们在水溶液中显示出高溶解度和稳定的分散性。载药量约为2527％。 m-SWNT和f-SWNT仅具有轻微的细胞毒性。 ETO在低pH下从EGF / CHI / SWNTCOOHs / ETO中释放出来，并通过三磷酸腺苷（ATP）依赖性的内吞作用被肿瘤细胞吸收。 EGF / CHI / SWNTCOOHs / ETO诱导的细胞死亡是单独使用ETO引起的细胞死亡的2.7倍。总之，这些结果表明，我们的TDDS比游离ETO体外具有更大的抗癌作用。

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