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Synthesis of nano-textured biocompatible scaffolds from chicken eggshells

机译：由鸡卵壳合成纳米结构生物相容性支架

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摘要

Cell adhesion, morphology and growth are influenced by surface topography at nano and micrometer scales. Nano-textured surfaces are prepared using photolithography, plasma etching and long polymer chemical etching which are cost prohibitive and require specialized equipment. This article demonstrates a simple approach to synthesize nano-textured scaffolds from chicken eggshells. Varieties of pattern are made on the eggshells like micro-needle forests and nanopores, giving very uniform nano-textures to the surfaces. The surfaces are characterized for chemical composition and crystal phase. The novel patterns are transferred to PDMS surfaces and the nano-textured PDMS surfaces are used to study the effect of texturing on human fibroblast cell growth and attachment. The effects of surface topographies, along with laminin coating on cell cultures, are also studied. We find an exciting phenomenon that the initial seeding density of the fibroblast cells affects the influence of the nano-texturing on cell growth. These nano-textured surfaces give 16 times more fibroblast growth when compared to flat PDMS surfaces. The novel nano-textured patterns also double the laminin adsorption on PDMS.
机译：细胞粘附，形态和生长受纳米和微米级表面形貌的影响。使用光刻，等离子蚀刻和长聚合物化学蚀刻来制备纳米纹理表面，这些成本高昂且需要专门的设备。本文展示了一种简单的方法，可以从鸡蛋壳中合成纳米质构支架。在蛋壳上制作出各种图案，例如微针森林和纳米孔，使表面具有非常均匀的纳米纹理。表面具有化学成分和晶相的特征。将新颖的图案转移至PDMS表面，并使用纳米纹理的PDMS表面来研究纹理化对人成纤维细胞生长和附着的影响。还研究了表面形貌以及层粘连蛋白涂层对细胞培养的影响。我们发现令人兴奋的现象是，成纤维细胞的初始接种密度会影响纳米纹理对细胞生长的影响。与平坦的PDMS表面相比，这些具有纳米纹理的表面使成纤维细胞的生长增加了16倍。新颖的纳米纹理图案还将层粘连蛋白在PDMS上的吸附量增加了一倍。

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