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Perovskite ceramic nanoparticles in polymer composites for augmenting bone tissue regeneration

机译：聚合物复合物中的钙钛矿陶瓷纳米颗粒可增强骨组织再生

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There is increasing interest in the use of nanoparticles as fillers in polymer matrices to develop biomaterials which mimic the mechanical, chemical and electrical properties of bone tissue for orthopaedic applications. The objective of this study was to prepare poly(epsilon-caprolactone) (PCL) nanocomposites incorporating three different perovskite ceramic nanoparticles, namely, calcium titanate (CT), strontium titanate (ST) and barium titanate (BT). The tensile strength and modulus of the composites increased with the addition of nanoparticles. Scanning electron microscopy indicated that dispersion of the nanoparticles scaled with the density of the ceramics, which in turn played an important role in determining the enhancement in mechanical properties of the composite. Dielectric spectroscopy revealed improved permittivity and reduced losses in the composites when compared to neat PCL. Nanofibrous scaffolds were fabricated via electrospinning. Induction coupled plasma-optical emission spectroscopy indicated the release of small quantities of Ca+2, Sr+2, Ba+2 ions from the scaffolds. Piezo-force microscopy revealed that BT nanoparticles imparted piezoelectric properties to the scaffolds. In vitro studies revealed that all composites support osteoblast proliferation. Expression of osteogenic genes was enhanced on the nanocomposites in the following order: PCL/CT>PCL/ST>PCL/BT>PCL. This study demonstrates that the use of perovskite nanoparticles could be a promising technique to engineer better polymeric scaffolds for bone tissue engineering.
机译：使用纳米颗粒作为聚合物基体中的填料的兴趣日益浓厚，以开发出可模仿骨组织的机械，化学和电学性质的生物材料，以用于整形外科领域。这项研究的目的是制备包含三种不同钙钛矿陶瓷纳米粒子的聚（ε-己内酯）（PCL）纳米复合材料，分别是钛酸钙（CT），钛酸锶（ST）和钛酸钡（BT）。复合材料的拉伸强度和模量随纳米颗粒的添加而增加。扫描电子显微镜表明，纳米颗粒的分散度与陶瓷的密度成比例，这反过来在确定复合材料机械性能的提高中起着重要的作用。与纯PCL相比，介电谱显示复合材料的介电常数提高，损耗减少。纳米纤维支架是通过静电纺丝制造的。感应耦合等离子体发射光谱表明从支架中释放出少量的Ca + 2，Sr + 2，Ba + 2离子。压电显微镜显示，BT纳米颗粒赋予了支架压电性能。体外研究表明，所有复合材料均支持成骨细胞增殖。成骨基因的表达按以下顺序在纳米复合材料上增强：PCL / CT> PCL / ST> PCL / BT> PCL。这项研究表明，钙钛矿纳米颗粒的使用可能是一种有前途的技术，可以为骨组织工程设计更好的聚合物支架。

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