• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Magnetite nanoparticle interactions with insulin amyloid fibrils
【24h】

Magnetite nanoparticle interactions with insulin amyloid fibrils

机译：磁铁矿纳米颗粒与胰岛素淀粉样原纤维的相互作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Accumulation of amyloid fibrils is one of the likely key factors leading to the development of Alzheimer's disease and other amyloidosis associated diseases. Magnetic nanoparticles (NPs) have been developed as promising medical materials for many medical applications. In this study, we have explored the effects of Fe3O4 NPs on the fibrillogenesis process of insulin fibrils. When Fe3O4 NPs were co-incubated with insulin, Fe3O4 NPs had no effect on the structural transformation into amyloid-like fibrils but had higher affinity toward insulin fibrils. We demonstrated that the zeta potential of insulin fibrils and Fe3O4 NPs were both positive, suggesting the binding forces between Fe3O4 NPs and insulin fibrils were van der Waals forces but not surface charge. Moreover, a different amount of Fe3O4 NPs added had no effect on secondary structural changes of insulin fibrils. These results propose the potential use of Fe3O4 NPs as therapeutic agents against diseases related to protein aggregation or contrast agents for magnetic resonance imaging.
机译：淀粉样蛋白原纤维的积累是导致阿尔茨海默氏病和其他淀粉样变性病相关疾病发展的可能关键因素之一。磁性纳米颗粒（NPs）已被开发为用于许多医疗应用的有前途的医疗材料。在这项研究中，我们探讨了Fe3O4 NPs对胰岛素原纤维原纤维形成过程的影响。当Fe3O4 NPs与胰岛素共孵育时，Fe3O4 NPs对结构转化为淀粉样蛋白样原纤维没有影响，但对胰岛素原纤维的亲和力更高。我们证明胰岛素原纤维和Fe3O4 NPs的ζ电位都为正，表明Fe3O4 NPs和胰岛素原纤维之间的结合力是范德华力，而不是表面电荷。此外，添加不同量的Fe3O4 NP对胰岛素原纤维的二级结构变化没有影响。这些结果表明，Fe3O4 NPs可能用于治疗与蛋白质聚集有关的疾病或磁共振成像造影剂。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号