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首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2.
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Changed accumbal responsiveness to alcohol in rats pre-treated with nicotine or the cannabinoid receptor agonist WIN 55,212-2.

机译：尼古丁或大麻素受体激动剂WIN 55,212-2预处理的大鼠对酒精的伏打反应有所改变。

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Alcohol, nicotine, and cannabinoid acutely increase the activity of the mesolimbic dopamine (DA) pathway. Although polysubstance consumption is a common pattern of abuse in humans, little is known about dopamine release following pre-exposure to these drugs. The purpose of this study was to test whether alcohol-induced dopamine release into the nucleus accumbens (NAc) shell is modified by different pre-treatments: water (i.g.), alcohol (1g/kg, i.g.), nicotine (0.4mg/kg, s.c.), and WIN 55,212-2 (1mg/kg, s.c.). Male Wistar rats were treated (i.g.) for 14 days with either water or alcohol. In the following 5 days rats were injected (s.c.) with vehicle, nicotine, or WIN 55,212-2. Finally, a cannula was surgically implanted into the NAc shell and alcohol-induced extracellular dopamine release was monitored in freely moving rats. Alcohol (1g/kg; i.g.) only increased the release of dopamine when animals were previously treated with water. This DA increase was markedly inhibited by (subchronic) treatment (5 days) with nicotine or WIN 55-212-2 as well as by previous (chronic) exposure to alcohol (14 days). These data demonstrate that pre-treatment with nicotine and the cannabinoid agonist WIN 55,212-2 is able to change the sensitivity of the NAc shell in response to a moderate dose of alcohol. Therefore, cannabinoid and nicotine exposure may have important implications on the rewarding effects of alcohol, because these drugs lead to long-lasting changes in accumbal dopamine transmission.
机译：酒精，尼古丁和大麻素会急剧增加中脑边缘多巴胺（DA）途径的活性。尽管多物质消费是人类常见的滥用方式，但对这些药物预先暴露后的多巴胺释放知之甚少。这项研究的目的是测试酒精诱导的多巴胺释放到伏隔核（NAc）壳中是否通过不同的预处理进行了修饰：水（ig），酒精（1g / kg，ig），尼古丁（0.4mg / kg ，sc）和WIN 55,212-2（1mg / kg，sc）。将雄性Wistar大鼠用水或酒精治疗（例如）14天。在接下来的5天中，向大鼠注射（s.c.）溶媒，尼古丁或WIN 55,212-2。最后，通过外科手术将套管植入NAc外壳，并在自由移动的大鼠中监测酒精诱导的细胞外多巴胺释放。酒精（1g / kg; i.g.）仅在事先用水对动物进行处理时才会增加多巴胺的释放。 DA的增加受到尼古丁或WIN 55-212-2的（亚慢性）治疗（5天）以及先前（长期）暴露于酒精（14天）的明显抑制。这些数据表明，用尼古丁和大麻素激动剂WIN 55,212-2进行预处理能够响应中等剂量的酒精而改变NAc外壳的敏感性。因此，大麻素和尼古丁暴露可能对酒精的奖励作用具有重要意义，因为这些药物会导致累积的多巴胺传递发生长期变化。

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