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首页> 外文期刊>Behavioural pharmacology >Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2.
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Behavioral effects in adult rats of chronic prepubertal treatment with the cannabinoid receptor agonist WIN 55,212-2.

机译：大麻素受体激动剂WIN 55,212-2对慢性青春期前成年大鼠的行为影响。

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摘要

Human and animal studies provide evidence for vulnerable periods of brain development for deleterious effects of cannabinoids. We have recently shown that pubertal chronic cannabinoid treatment leads to long-lasting behavioral deficits, whereas a comparable treatment in adult rats did not affect the animals' behavior. In the present study we examined the effects of an identical chronic cannabinoid treatment in juvenile rats, just before the onset of puberty. Treatment with the synthetic cannabinoid agonist WIN 55,212-2 (WIN) (1.2 mg/kg) or vehicle was extended over 25 days throughout the prepubertal period (postnatal days 15-40) in juvenile rats. The rats received a total of 20 injections intraperitoneally. Adult rats were tested for object recognition memory, performance in a progressive ratio (PR) operant behavior task, locomotor activity and prepulse inhibition (PPI) of the acoustic startle response. Juvenile chronic WIN administration had no effect on object recognition memory, PR performance and locomotor activity in adulthood. However, a PPI deficit was observed in WIN-treated rats when tested as adults that could be reversed by the acute administration of the dopamine receptor antagonist haloperidol (0.1 mg/kg). Additionally, juvenile cannabinoid treatment reduced the number of rearings, as well as the time spent in the center of the open field in adult rats, suggesting increased anxiety. Juvenile chronic cannabinoid treatment induced behavioral disturbances in adult rats that are less severe than those observed after pubertal cannabinoid administration. However, based on the observations of sensorimotor gating deficits and increased anxiety, we conclude that the prepubertal developmental phase, in addition to puberty, also represents a vulnerable time period for persistent adverse effects of cannabinoids.
机译：人类和动物研究为大麻素的有害作用提供了大脑发育脆弱时期的证据。我们最近显示，青春期慢性大麻素治疗可导致长期的行为缺陷，而成年大鼠的类似治疗并不会影响动物的行为。在本研究中，我们研究了在青春期即将来临之前，对幼年大鼠进行相同的慢性大麻素治疗的效果。在幼年期的整个青春期前（出生后15-40天），用合成大麻素激动剂WIN 55,212-2（WIN）（1.2 mg / kg）或赋形剂进行的治疗延长了25天。大鼠腹膜内总共注射20次。测试了成年大鼠的对象识别记忆力，在进行性比率（PR）操作行为任务中的表现，运动活动和听觉惊吓反应的前脉冲抑制（PPI）。少年慢性WIN给药对成年对象识别记忆，PR性能和运动活动没有影响。但是，当成年测试时，在WIN治疗的大鼠中观察到PPI缺乏，可以通过急性给予多巴胺受体拮抗剂氟哌啶醇（0.1 mg / kg）逆转。此外，青少年大麻素治疗减少了成年大鼠的饲养次数以及在旷野中心所花费的时间，表明焦虑增加了。少年慢性大麻素治疗可导致成年大鼠的行为障碍，其严重程度低于青春期大麻素给药后的行为障碍。但是，基于对感觉运动门控功能缺陷和焦虑增加的观察，我们得出的结论是，青春期前的青春期前发育阶段也代表了大麻素持续不良作用的脆弱时期。

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