Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

Yamamoto Toshifumi; Nakayama Tomomi; Yamaguchi Junji; Matsuzawa Maaya; Mishina Masayoshi; Ikeda Kazutaka; Yamamoto Hideko

首页> 外文期刊>Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences >Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

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Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

机译：NMDA受体GluN2D亚基在氯胺酮表达引起的行为敏化和神经元一氧化氮合酶区域特异性激活的表达中的作用

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The present study aimed to investigate the involvement of the NMDA receptor (NMDAR) and/or nitric oxide (NO) pathway in ketamine-induced behavioral sensitization. Mice received repeated subcutaneous administration of ketamine (25 mg/kg), once daily or once weekly for a total of five doses. Even three administrations of ketamine, daily or weekly, induced a rapid increase in locomotor activity in wildtype (WT), but not in GluN2D knockout (GluN2D-KO) mice. Furthermore, for WT mice receiving daily ketamine, elevated locomotor activity was maintained after a 1-month withdrawal period; however, this was not the case when ketamine was administered weekly.

机译：本研究旨在调查NMDA受体（NMDAR）和/或一氧化氮（NO）途径在氯胺酮诱导的行为敏化中的作用。小鼠每天一次或每周一次重复皮下注射氯胺酮（25 mg / kg），共五剂。即使每天或每周进行三次氯胺酮给药，也会在野生型（WT）小鼠中引起运动活性的快速增加，但在GluN2D基因敲除（GluN2D-KO）小鼠中却没有。此外，对于每日接受氯胺酮的野生型小鼠，在停药1个月后，其运动活性得以维持。但是，每周服用氯胺酮的情况并非如此。

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来源
《Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences》 |2016年第1期|共6页
作者
Yamamoto Toshifumi; Nakayama Tomomi; Yamaguchi Junji; Matsuzawa Maaya; Mishina Masayoshi; Ikeda Kazutaka; Yamamoto Hideko;
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正文语种 eng
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关键词
Ketamine; GluN2D; Knockout; Neuronal nitric oxide synthase; Sensitization;

机译：氯胺酮;GluN2D;敲除;神经型一氧化氮合酶;敏化;

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1. Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase [J] . Yamamoto Toshifumi, Nakayama Tomomi, Yamaguchi Junji, Neuroscience Letters: An International Multidisciplinary Journal Devoted to the Rapid Publication of Basic Research in the Brain Sciences . 2016,第1期

机译：NMDA受体GluN2D亚基在氯胺酮表达引起的行为敏化和神经元一氧化氮合酶区域特异性激活的表达中的作用
2. Role of nitric oxide synthase inhibitors and NMDA receptor antagonist in nicotine-induced behavioral sensitization in the rat. [J] . Shim I, Kim HT, Kim YH, European Journal of Pharmacology: An International Journal . 2002,第1a3期

机译：一氧化氮合酶抑制剂和NMDA受体拮抗剂在尼古丁诱导的大鼠行为敏化中的作用。
3. Metabotropic glutamate receptor 5, but not 1, modulates NMDA receptor-mediated activation of neuronal nitric oxide synthase. [J] . Llansola M, Felipo V Neurochemistry International: The International Journal for the Rapid Publication of Critical Reviews, Preliminary and Original Research Communications in Neurochemistry . 2010,第4期

机译：代谢型谷氨酸受体5（而不是1）调节NMDA受体介导的神经元一氧化氮合酶的活化。
4. Enhanced AMPA Receptor GluR1 Subunit Expression and Neuronal Activation within Brainstem Pain Modulatory Circuitry after Inflammation [C] . Cynthia L. Renn, Yun Guan, Ronald Dubner, World Congress on Pain . 2003

机译：增强型AMPA受体Glur1亚基表达和脑干疼痛调节电路中的神经元激活
5. Differences in the activation of endothelial and neuronal nitric oxide synthase by oxidized calmodulin, and multiphoton activation of a photo-sensitive nitric oxide synthase inhibitor. [D] . Montgomery, Heather Jane. 2004

机译：氧化钙调蛋白活化内皮和神经元一氧化氮合酶的差异，以及光敏一氧化氮合酶抑制剂的多光子活化。
6. Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures [O] . Xavier DAnglemont De Tassigny, Céline Campagne, Sophie Steculorum, -1

机译：雌二醇诱导神经元一氧化氮合酶与NMDA受体的物理缔合并通过初级神经元培养物中的雌激素受体激活促进一氧化氮形成。
7. Estradiol induces physical association of neuronal nitric oxide synthase with NMDA receptor and promotes nitric oxide formation via estrogen receptor activation in primary neuronal cultures. [O] . De Tassigny, Xavier D'Anglemont, Campagne, Céline, Steculorum, Sophie, 2009

机译：雌二醇诱导神经元一氧化氮合酶与NMDA受体的物理缔合，并通过初级神经元培养物中的雌激素受体活化促进一氧化氮的形成。

Role of the NMDA receptor GluN2D subunit in the expression of ketamine-induced behavioral sensitization and region-specific activation of neuronal nitric oxide synthase

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