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首页> 外文期刊>Neuroscience: An International Journal under the Editorial Direction of IBRO >REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ENHANCES SPATIAL LEARNING AND SYNAPTIC PLASTICITY VIA THE VEGF AND BDNF-NMDAR PATHWAYS IN A RAT MODEL OF VASCULAR DEMENTIA
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REPETITIVE TRANSCRANIAL MAGNETIC STIMULATION ENHANCES SPATIAL LEARNING AND SYNAPTIC PLASTICITY VIA THE VEGF AND BDNF-NMDAR PATHWAYS IN A RAT MODEL OF VASCULAR DEMENTIA

机译：重复性经颅磁刺激通过血管性痴呆大鼠模型中的VEGF和BDNF-NMDAR通路增强空间学习和突触可塑性

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This study aimed to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) on learning and memory in a rat model of vascular dementia (VaD) and to analyze the associated mechanisms. Bilateral carotid artery occlusion (2-VO) was used to establish a rat model of VaD. High-frequency (5 Hz) rTMS was performed on rats for four weeks. Spatial learning and memory abilities were evaluated using the Morris water maze (MWM), and synaptic plasticity in the hippocampus was assessed via long-term potentiation (LTP). Hippocampal expression of vascular endothelial growth factor (VEGF), brain-derived neurotrophic factor (BDNF) and three subunits of the N-methyl-D-aspartic acid receptor (NMDAR), NR1, NR2A and NR2B, was analyzed by Western blotting. Compared with the VaD group, escape latency was decreased (P< 0.05) and the time spent in the target quadrant and the percentage of swimming distance within that quadrant were increased (P< 0.05) in the rTMS group. LTP at hippocampal CA3-CA1 synapses was enhanced by rTMS (P< 0.05). VEGF expression was up-regulated following 2-VO and was further increased by rTMS (P< 0.05). BDNF, NR1 and NR2B expression was decreased in the VaD group and increased by rTMS (P< 0.05). There were no significant differences in NR2A expression among the three groups. These results suggest that rTMS improved learning and memory in the VaD model rats via the up-regulation of VEGF, BDNF and NMDARs. In addition, NR2B may be more important than NR2A for LTP induction in the hippocampus during rTMS treatment of VaD. (C) 2015 IBRO. Published by Elsevier Ltd. All rights reserved.
机译：这项研究旨在评估重复性经颅磁刺激（rTMS）对血管性痴呆（VaD）大鼠模型中学习和记忆的影响，并分析相关机制。使用双侧颈动脉闭塞（2-VO）建立VaD大鼠模型。对大鼠进行了高频（5 Hz）rTMS，持续了四个星期。使用莫里斯水迷宫（MWM）评估空间学习和记忆能力，并通过长期增强（LTP）评估海马突触可塑性。通过蛋白质印迹法分析了海马中血管内皮生长因子（VEGF），脑源性神经营养因子（BDNF）和N-甲基-D-天冬氨酸受体（NMDAR）的三个亚基NR1，NR2A和NR2B的表达。与VaD组相比，rTMS组的逃避潜伏期缩短（P <0.05），在目标象限花费的时间和在该象限内的游泳距离百分比增加（P <0.05）。 rTMS增强海马CA3-CA1突触的LTP（P <0.05）。 2-VO后VEGF表达上调，并通过rTMS进一步增加（P <0.05）。 VaD组BDNF，NR1和NR2B表达降低，而rTMS升高（P <0.05）。三组之间的NR2A表达没有显着差异。这些结果表明，rTMS通过上调VEGF，BDNF和NMDARs来改善VaD模型大鼠的学习和记忆。另外，在rTMS治疗VaD期间，对于海马中的LTP诱导，NR2B可能比NR2A更重要。 （C）2015年IBRO。由Elsevier Ltd.出版。保留所有权利。

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