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首页> 外文期刊>RSC Advances >Synthesis of a new class of pyrazole embedded spirocyclic scaffolds using magnetically separable Fe3O4@SiO2-SO3H nanoparticles as recyclable solid acid support
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Synthesis of a new class of pyrazole embedded spirocyclic scaffolds using magnetically separable Fe3O4@SiO2-SO3H nanoparticles as recyclable solid acid support

机译：以磁性可分离的Fe3O4 @ SiO2-SO3H纳米粒子为可循环利用的固体酸载体合成新型吡唑嵌入的螺环骨架

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摘要

An efficient, green and sustainable methodology for the synthesis of a new class of pyrazole embedded spirocyclic scaffolds has been developed. The method involves the condensation of a tetrone with a variety of arylhydrazones in the presence of Fe3O4@SiO2-SO3H magnetic nanoparticles (MNPs) as solid supported acid catalyst under solvent-free conditions. An interesting tandem rearrangement of the in situ generated adducts, derived from the acid catalyzed condensation of tetrone and arylhydrazones, leads to the formation of pyrazole embedded spirocyclic scaffolds. The significant advantages of this methodology are the use of solvent-free reaction conditions, employment of simple and easily available starting materials and reagents, good yields of the products with high atom-economy and operational simplicity of the reaction with the use of a magnetically separable and recyclable nano catalyst.
机译：已经开发了一种高效，绿色和可持续的方法，用于合成新型的吡唑嵌入的螺环支架。该方法包括在无溶剂条件下，在作为固体负载型酸催化剂的Fe3O4 @ SiO2-SO3H磁性纳米粒子（MNP）存在下，将四氢噻酮与各种芳基hydr缩合。原位生成的加合物的有趣的串联重排，是由酸催化的四酮和芳基hydr缩合物的缩合反应，导致吡唑包埋的螺环骨架的形成。该方法的显着优点是：使用无溶剂的反应条件，使用简单易用的起始原料和试剂，具有高原子经济性的产物具有良好的收率以及使用可磁分离的反应操作简便和可回收的纳米催化剂。

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