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首页> 外文期刊>RSC Advances >Designing a novel nanocomposite for bone tissue engineering using electrospun conductive PBAT/polypyrrole as a scaffold to direct nanohydroxyapatite electrodeposition
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Designing a novel nanocomposite for bone tissue engineering using electrospun conductive PBAT/polypyrrole as a scaffold to direct nanohydroxyapatite electrodeposition

机译：使用电纺导电PBAT /聚吡咯作为支架引导纳米羟基磷灰石电沉积，设计用于骨组织工程的新型纳米复合材料

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Electrospinning is a well-recognized technique for producing nanostructured fibers capable of supporting cell adhesion and further proliferation. Here, we prepared a novel electrospun blend from poly(butylene adipate-co-terephthalate) (PBAT), a non-conductive and biodegradable polymer, and a conductive polymer, namely polypyrrole (PPy). Therefore, the goal was to create electrically conductive nanoscaffolds for tissue engineering applications. Furthermore, to improve the scaffold biomimetic features for bone regeneration purposes, we demonstrated the feasibility of electrodepositing nanohydroxyapatite (nHAp) onto the new hybrid scaffold. Electrochemical measurements confirmed the electrical conductivity of the novel PBAT/PPy scaffold, which allowed nHAp electrodeposition, further confirmed via ATR-FTIR analysis and FE-SEM micrographs. The PPy loading did not change the fibers' average diameter, although the increase in the solution conductivity was probably responsible for leading to electrospun mats with smaller beads and a lower presence of flattened regions compared to PBAT neat. The hybrid scaffold was more hydrophilic than PBAT neat. The first presented an advanced contact angle (ACA) of 84 degrees, whilst the latter presented an ACA of 115 degrees. The incorporation of PPy to PBAT maintained the ability of the generated scaffold to support cell adhesion with no changes in MG-63 cell viability. However, the PBAT/PPy scaffold presented higher values of alkaline phosphatase, an important indicator of osteoblasts differentiation. In conclusion, we demonstrated a feasible approach to create electrically conductive nanoscaffolds, which are capable of undergoing nHAp electrodeposition in order to generate materials that are more hydrophilic with improved cell differentiation. These results show the potential of application of this novel scaffold towards bone regenerative medicine.
机译：电纺丝是用于生产能够支持细胞粘附和进一步增殖的纳米结构纤维的公认技术。在这里，我们从聚己二酸丁二酯-对苯二甲酸对苯二甲酸酯（PBAT），一种不可导电且可生物降解的聚合物和一种导电聚合物（即聚吡咯（PPy））制备了一种新型的电纺共混物。因此，目标是创建用于组织工程应用的导电纳米支架。此外，为了改善用于骨骼再生目的的支架仿生特性，我们证明了将纳米羟基磷灰石（nHAp）电沉积到新的混合支架上的可行性。电化学测量证实了新型PBAT / PPy支架的电导率，该支架允许nHAp电沉积，并通过ATR-FTIR分析和FE-SEM显微照片进一步证实。尽管溶液电导率的增加可能导致电纺垫具有较小的珠粒，并且与纯PBAT相比，扁平区域的存在较少，但PPy的载荷并未改变纤维的平均直径。杂种支架比纯PBAT亲水性更高。前者提供了84度的超前接触角（ACA），而后者则提供了115度的ACA。 PPy与PBAT的结合保持了所产生的支架支持细胞粘附的能力，而MG-63细胞活力没有变化。然而，PBAT / PPy支架表现出更高的碱性磷酸酶值，碱性磷酸酶是成骨细胞分化的重要指标。总之，我们证明了创建导电纳米支架的可行方法，该支架能够进行nHAp电沉积，以产生亲水性更高的细胞分化材料。这些结果表明该新型支架在骨再生医学中的应用潜力。

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