Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions

Wang Zhipeng A.; Ding Xiaozhe Z.; Tian Chang-Lin; Zheng Ji-Shen

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Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions

机译：蛋白质/肽二级结构模拟物：蛋白质-蛋白质相互作用的设计，表征和调节

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Protein-protein interactions (PPIs) play a critical role in many essential biological processes, and numerous diseases result from malfunctioning PPIs. The modulation of undesirable PPIs via synthetic chemical molecules has long been considered of medical importance, but still remains challenging. Thanks to the development of synthetic chemistry, chemists can synthesize protein/peptide secondary structure mimics to modulate the specific PPIs. This review discusses general aspects of novel artificial peptide secondary structure mimics for the modulation of PPIs, their therapeutic applications and future prospects.

机译：蛋白质-蛋白质相互作用（PPI）在许多必不可少的生物学过程中起着至关重要的作用，并且由于PPI的功能异常而导致多种疾病。长期以来，人们一直认为通过合成化学分子对不良PPI进行调节具有医学重要性，但仍具有挑战性。由于合成化学的发展，化学家可以合成蛋白质/肽二级结构模拟物来调节特定的PPI。这篇综述讨论了新型人工肽二级结构模拟物的一般方面，用于调节PPI，其治疗应用和未来前景。

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《RSC Advances》 |2016年第66期|共11页
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Wang Zhipeng A.; Ding Xiaozhe Z.; Tian Chang-Lin; Zheng Ji-Shen;
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1. Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions [J] . Wang Zhipeng A., Ding Xiaozhe Z., Tian Chang-Lin, RSC Advances . 2016,第66期

机译：蛋白质/肽二级结构模拟物：蛋白质-蛋白质相互作用的设计，表征和调节
2. Modulation of protein-protein interactions by stabilizing/mimicking protein secondary structure elements. [J] . de-Vega MJ, Martin-Martinez M, Gonzalez-Muniz R Current topics in medicinal chemistry . 2007,第1期

机译：通过稳定/模拟蛋白质二级结构元素来调节蛋白质-蛋白质相互作用。
3. Modulation of Protein-Protein Interactions by Stabilizing/Mimicking Protein Secondary Structure Elements [J] . M. Jesus Perez de Vega Mercedes Martin-Martinez Rosario Gonzalez-Muniz Current Topics in Medicinal Chemistry . 2007,第1期

机译：通过稳定/模仿蛋白质二级结构元素的蛋白质-蛋白质相互作用的调节。
4. Characterization of Domain-Peptide Interaction Interface: Prediction of SH3 Domain-Mediated Protein-Protein Interaction Network in Yeast by Generic Structure-Based Models [C] . Tingjun Hou, Nan Li, Youyong Li, International conference of molecular simulations and applied informatics technologies . 2012

机译：域-肽相互作用界面的表征：基于通用结构的模型预测酵母中SH3域介导的蛋白质-蛋白质相互作用网络。
5. The Making and Breaking of Lipids: The Characterization of the Protein-Protein and Protein-Substrate Interactions and Bioengineering of Type II Fatty Acid Synthases FabA and AcpP and the Structural and Functional Characterization of Iterative Type I Trans-Acting Enoyl-Reductase, LovC Polyketide Synthase. [D] . Nguyen, Chi Hanh Thi. 2014

机译：脂质的产生和断裂：II型脂肪酸合酶FabA和AcpP的蛋白质-蛋白质和蛋白质-底物相互作用的表征和生物工程以及I型迭代反式烯丙基还原酶，LovC聚酮合酶的结构和功能表征。
6. Comprehensive atomic-level characterization of structurally characterized protein-protein interactions: the PICCOLO database [O] . George R Bickerton, Alicia P Higueruelo, Tom L Blundell 2011

机译：全面的原子级表征结构上表征的蛋白质-蛋白质相互作用：PICCOLO数据库
7. Protein/peptide secondary structural mimics: design, characterization, and modulation of protein–protein interactions [O] . Wang, Zhipeng A., Ding, Xiaozhe Z., Tian, Chang-Lin, 2016

机译：蛋白质/肽二级结构模拟物：蛋白质-蛋白质相互作用的设计，表征和调节

Protein/peptide secondary structural mimics: design, characterization, and modulation of protein-protein interactions

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