Multicomponent synthesis of hydrazino depsipeptides

Suc Josipa; Baric Danijela; Jeric Ivanka

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Multicomponent synthesis of hydrazino depsipeptides

机译：肼基二肽的多组分合成

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摘要

The Passerini reaction of alpha-hydrazino acids, carbonyl compounds and isocyanides yielded hydrazino depsipeptides, a new class of backbone extended peptidomimetics comprising amide bond isostere. A wide range of carbonyl and isocyano components were used along the alpha-hydrazino acids carrying three different N-alpha protecting groups. The kinetics and thermodynamic equilibrium of the rate-determining step of the reaction with different alpha-hydrazino acids were studied by DFT approach.

机译：α-肼基酸，羰基化合物和异氰酸酯的Passerini反应产生肼基二肽，这是一类新型的由酰胺键等排物组成的骨架扩展拟肽。沿着带有三个不同N-α保护基的α-肼基酸使用了广泛的羰基和异氰基组分。通过DFT方法研究了与不同的α-肼基酸反应的速率决定步骤的动力学和热力学平衡。

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《RSC Advances》 |2016年第102期|共12页
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Suc Josipa; Baric Danijela; Jeric Ivanka;
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1. Multicomponent synthesis of hydrazino depsipeptides [J] . Suc Josipa, Baric Danijela, Jeric Ivanka RSC Advances . 2016,第102期

机译：肼基二肽的多组分合成
2. Efficient synthesis of lower rim alpha-hydrazino tetrazolocalix[4]arenes via an Ugi-azide multicomponent reaction [J] . Alavijeh Nahid S., Zadmard Reza, Ramezanpour Sorour, New Journal of Chemistry . 2015,第8期

机译：通过Ugi-叠氮化物多组分反应有效合成低边缘的α-肼四唑localix [4]芳烃
3. NOVEL ONE-POT MULTICOMPONENT SYNTHESIS OF SUBSTITUTED 2,3-DIHYDRO-2-(6-(4-HYDROXY-6-METHYL-2-OXO-2H-PYRAN-3-YL)-7H-[1,2,4]TRIAZOLO[3,4-b][1,3,4]THIADIAZIN-3-YL)PHTHALAZINE-1,4-DIONES AND SUBSTITUTED 3-[3-(N'-BENZYLIDENE-HYDRAZINO)-7H-[1,2,4] TRIAZOLO[3,4-b][1,3,4]THIADIAZIN-6-YL]-4-HYDROXY-6-METHYL-PYRAN-2-ONES [J] . Bade Thirupaiah, Rajeswar Rao Vedula Synthetic Communications . 2014,第4a6期

机译：取代的2,3-二氢-2-（6-（4-羟基-6-甲基-2-氧-2-氧-2H-吡喃-3-基）-7H- [1,2,4]的新颖一锅多组分合成TRIAZOLO [3,4-b] [1,3,4]噻二嗪-3-基）酞嗪-1,4-二酮和取代的3- [3-（N'-苄基-肼基）-7H- [1,2 ，4] TRIAZOLO [3,4-b] [1,3,4]噻二嗪-6-YL] -4-羟基-6-甲基-吡喃-2-酮
4. Laser sensitive primary explosives: synthesis and properties of complexes with 3-hydrazino-4-amino-1,2,4-triazole (HATr) as ligand [C] . Cai-Xia Xu, Jian-Guo Zhang, XinYin Seminar on New Trends in Research of Energetic Materials . 2016

机译：对激光敏感的初级炸药：以3-肼基-4-氨基-1,2,4-三唑（HATr）为配体的配合物的合成和性质
5. Biosynthesis of Antimycin-Type Depsipeptides and Cyclohexylcarbonyl-CoA [D] . Skyrud, David William. 2020

机译：抗霉素型Depsipeptips和环己基羰基 - COA的生物合成
6. Synthesis of hybrid hydrazino peptides: protected vs unprotected chiral α-hydrazino acids [O] . Josipa Suć, Ivanka Jerić -1

机译：杂合肼基肽的合成：受保护的和未保护的手性α-肼基酸
7. Multicomponent synthesis of hydrazino depsipeptides [O] . Suć Josipa, Barić Danijela, Jerić Ivanka 2016

机译：肼基二肽的多组分合成
8. Synthesis and Characterization of 5-(hydrazino-alkyl) Tetrazoles. [R] . Ahmed, Y., Schneider, S., Deplazes, S., 2014

机译：5-（肼基 - 烷基）四唑的合成与表征。

Multicomponent synthesis of hydrazino depsipeptides

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