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Gene expression homeostasis and chromosome architecture

机译：基因表达稳态和染色体结构

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In rapidly growing populations of bacterial cells, including those of the model organism Escherichia coli, genes essential for growth - such as those involved in protein synthesis - are expressed at high levels; this is in contrast to many horizontally-acquired genes, which are maintained at low transcriptional levels.1 This balance in gene expression states between 2 distinct classes of genes is established by a galaxy of transcriptional regulators, including the so-called nucleoid associated proteins (NAP) that contribute to shaping the chromosome.2 Besides these active players in gene regulation, it is not too farfetched to anticipate that genome organization in terms of how genes are arranged on the chromosome,3 which is the result of long-drawntransactions among genome rearrangement processes and selection, and the manner in which it is structured inside the cell, plays a role in establishing this balance. A recent study from our group has contributed to the literature investigating the interplay between global transcriptional regulators and genome organization in establishing gene expression homeostasis.4 In particular, we address a triangle of functional interactions among genome organization, gene expression homeostasis and horizontal gene transfer.
机译：在迅速增长的细菌细胞种群中，包括典型的大肠杆菌模型中，生长必需的基因（例如参与蛋白质合成的基因）以高水平表达。这与保持低转录水平的许多水平获得性基因形成对照。12种不同类别的基因之间的基因表达状态之间的这种平衡是由转录调节剂星系（包括所谓的类核蛋白相关蛋白（ （NAP）有助于染色体的形成。2除了基因调控中的这些活跃分子外，就基因在染色体上的排列方式3来预测基因组的组织并不太牵强，这是基因组之间长期交换的结果。重排过程和选择，以及细胞内部结构的方式，在建立这种平衡中发挥了作用。我们小组的最新研究为研究全球转录调节因子和基因组组织在建立基因表达稳态中的相互作用提供了文献。4特别是，我们探讨了基因组组织，基因表达稳态和水平基因转移之间功能相互作用的三角形。

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