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Molecular layer detection on a diffractive optical balance

机译:衍射光学天平上的分子层检测

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摘要

Diffraction-based molecular detection is achieved by etching optical gratings into thermal oxide on silicon. The gratings perform as a stable common-path diffractive optical balance (DOB) designed to operate near a missing diffraction order. The biosensor is operated in an off-null condition with a phase bias to produce a high-contrast responsivity that is linear in accumulated molecules but with a low background. The DOB linear responsivity is a factor of 20 larger than the reflectometric responsivity of planar thermal oxide.
机译:基于衍射的分子检测是通过将光栅刻蚀为硅上的热氧化物来实现的。光栅起到稳定的共通衍射光学天平(DOB)的作用,被设计为在缺少的衍射级附近工作。生物传感器在零相位状态下以相位偏置运行,以产生高对比度的响应度,该响应度在累积的分子中呈线性,但背景较低。 DOB线性响应度比平面热氧化物的反射响应度大20倍。

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