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首页> 外文期刊>Cornea >Comparison between laser scanning in vivo confocal microscopy and noncontact specular microscopy in assessing corneal endothelial cell density and central corneal thickness.
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Comparison between laser scanning in vivo confocal microscopy and noncontact specular microscopy in assessing corneal endothelial cell density and central corneal thickness.

机译：激光共聚焦共聚焦显微镜和非接触式镜面显微镜在评估角膜内皮细胞密度和中央角膜厚度之间的比较。

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PURPOSE: To compare central corneal thickness (CCT) and endothelial cell density (ECD) with laser scanning confocal microscope Heidelberg Retina Tomograph (HRT) II Rostock Corneal Module and noncontact specular microscope Tomey EM-3000 and to assess intra- and interobserver agreement in normal corneas. METHODS: This prospective study included 48 normals (69.6 +/- 7.2 years, range: 55-80 years) who underwent CCT and ECD with both Tomey and HRT 3 times by 2 independent observers. Measurement differences between instruments, agreement between devices, and test-retest variability (TRV) were determined. RESULTS: Mean CCTs with Tomey and HRT were 529.4 +/- 35.4 and 536 +/- 37.6 mum (P = 0.06), respectively; average ECDs with Tomey and HRT were 2473.5 +/- 242.2 and 2539.7 +/- 338.6 cells per square millimeter (P = 0.04), respectively. The mean of the differences (HRT minus Tomey) was 6.5 +/- 17 mum for CCT and 65 +/- 135.1 cells per square millimeter for ECD. Differences between instruments were not related to CCT (P = 0.35), whereas significantly increased with increasing ECD (P = 0.0001). Intraexaminer TRV for Tomey and HRT were 3.9 +/- 3.7 and 22.2 +/- 18.4 mum for CCT and 73 +/- 63.4 and 152.2 +/- 148.4 cells per square millimeter for ECD, respectively; interexaminer TRV was 4.6 +/- 4.2 and 23.8 +/- 17.3 mum for CCT and 84.9 +/- 72.3 and 159.8 +/- 149.8 cells per square millimeter for ECD. CONCLUSIONS: HRT II Rostock Corneal Module and the Tomey EM-3000 showed an overall good intermethod agreement. HRT showed a tendency to slightly overestimate CCT measurements, significantly underestimate ECD measurements in eyes with a reduced cell density (< 2290 cells per square millimeter), and overestimate ECD in eyes with a high cell density. Both instruments showed low intra- and interobserver TRV for both CCT and ECD measurements, which tended to be less for Tomey.
机译：目的：使用激光扫描共聚焦显微镜海德堡视网膜断层扫描仪（HRT）II Rostock角膜组件和非接触式镜面显微镜Tomey EM-3000来比较中心角膜厚度（CCT）和内皮细胞密度（ECD），并评估正常观察者与观察者之间的一致性角膜。方法：这项前瞻性研究包括48位正常人（69.6 +/- 7.2岁，范围：55-80岁），他们由2位独立观察者进行了3次均接受Tomy和HRT的CCT和ECD治疗。确定了仪器之间的测量差异，设备之间的一致性以及重测变异性（TRV）。结果：Tomey和HRT的平均CCT分别为529.4 +/- 35.4和536 +/- 37.6妈妈（P = 0.06）; Tomey和HRT的平均ECD分别为2473.5 +/- 242.2和2539.7 +/- 338.6细胞/平方毫米（P = 0.04）。对于CCT，差异的平均值（HRT减去Tomey）为6.5 +/- 17毫米，对于ECD，差异为65 / + /-135.1每平方毫米。仪器之间的差异与CCT无关（P = 0.35），而随着ECD的增加而显着增加（P = 0.0001）。 Tomey和HRT的Intraexaminer TRV对于CCT而言分别为3.9 +/- 3.7和22.2 +/- 18.4毫米，对于ECD而言分别为73 +/- 63.4和152.2 +/- 148.4个/毫米。对于CCT，检查者间TRV为4.6 +/- 4.2和23.8 +/- 17.3毫米，对于ECD为84.9 +/- 72.3和159.8 +/- 149.8个/毫米。结论：HRT II罗斯托克角膜模块和Tomey EM-3000显示出总体良好的方法间协议。 HRT表现出稍微高估CCT测量的趋势，在细胞密度降低（每平方毫米<2290个细胞）的眼睛中，ECD测量明显低估，在高细胞密度的眼睛中，ECD测量过高的趋势。两种仪器均显示CCT和ECD的观察者内和观察者间TRV较低，而对于Tomey而言则较小。

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