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首页> 外文期刊>Cornea >The relationship between human papillomavirus and p53 gene in conjunctival squamous cell carcinoma.
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The relationship between human papillomavirus and p53 gene in conjunctival squamous cell carcinoma.

机译：结膜鳞状细胞癌中人乳头瘤病毒与p53基因的关系。

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PURPOSE: The p53 tumor-suppressor gene has been documented to exist in mutated forms in many types of squamous cell carcinoma in the body. Also in conjunctival squamous cell carcinoma, human papillomavirus (HPV) is accepted as an oncogenic factor. The objective of our study was to establish a correlation between p53 overexpression and the presence of HPV infection within tumor tissues from patients with conjunctival squamous cell carcinoma. METHODS: Tissue sections obtained from paraffin-embedded conjunctival squamous cell carcinoma specimens from 23 patients were examined with light microscopy, polymerase chain reaction (PCR), and immunohistochemistry. RESULTS: Seventy-eight percent of tumors were positive for p53, whereas 22% were positive for HPV. The proportion of patients positive for both p53 and HPV was 17%, whereas another 17% of the patients were negative for both p53 and HPV. Therefore no significant disproportion was found in the distribution of patients' HPV status and p53 status (p = 1.00). No significant correlation or linear association was found between the HPV status and p53 status (r = 0.022; p = 0.920). CONCLUSION: We could not show any statistical association between abnormal p53 gene-product expression by immunohistochemistry in conjunctival squamous cell carcinomas and HPV infection by PCR detection techniques.
机译：目的：已证明p53肿瘤抑制基因以突变形式存在于体内多种类型的鳞状细胞癌中。同样在结膜鳞状细胞癌中，人乳头瘤病毒（HPV）被认为是致癌因子。我们研究的目的是建立结膜鳞状细胞癌患者的肿瘤组织内p53过度表达与HPV感染之间的相关性。方法：对23例石蜡包埋的结膜鳞状细胞癌标本中的组织切片进行光学显微镜，聚合酶链反应（PCR）和免疫组织化学检查。结果：78％的肿瘤p53阳性，而22％的HPV阳性。 p53和HPV均为阳性的患者比例为17％，而p53和HPV均为阴性的患者比例为17％。因此，在患者HPV状态和p53状态的分布中未发现明显的不均衡（p = 1.00）。在HPV状态和p53状态之间未发现显着相关性或线性关联（r = 0.022; p = 0.920）。结论：我们未发现结膜鳞状细胞癌中免疫组织化学检测到的p53基因产物异常表达与PCR检测技术感染HPV之间有任何统计学联系。

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