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首页> 外文期刊>Critical reviews in clinical laboratory sciences >Clinical significance of cytokine determination in synovial fluid.
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Clinical significance of cytokine determination in synovial fluid.

机译：滑液中细胞因子测定的临床意义。

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Cytokines are a complex family of small regulatory proteins able to mediate intercellular communication and play a crucial role in immunologic and inflammatory reactions. Many reports have demonstrated that some cytokines, in particular tumor necrosis factor alpha (TNFalpha) and interleukin (IL)-1beta, IL-6, and IL-8, so-called proinflammatory, may have a major role in the pathogenesis of joint diseases. Thus, high levels of these substances have been found in inflammatory arthropathies, in particular in those characterized by a more aggressive and destructive outcome, such as rheumatoid arthritis, gout, and infectious arthritis. In keeping with their role, the determination of cytokines in synovial fluid may be proposed for clinical purposes, including diagnostic and prognostic assessments. Furthermore, as some of these cytokines may reflect disease activity, their determination may also be useful in the evaluation of therapy.
机译：细胞因子是一个复杂的小调节蛋白家族，能够介导细胞间通讯并在免疫和炎症反应中起关键作用。许多报告表明，某些细胞因子，特别是肿瘤坏死因子α（TNFalpha）和白介素（IL）-1beta，IL-6和IL-8，所谓的促炎性，可能在关节疾病的发病机理中起主要作用。因此，已经在炎症性关节病中发现了这些物质的高水平，特别是在以更具侵略性和破坏性的结果为特征的那些中，例如类风湿性关节炎，痛风和传染性关节炎。与它们的作用保持一致，滑膜液中细胞因子的测定可建议用于临床目的，包括诊断和预后评估。此外，由于这些细胞因子中的某些可能反映疾病活动，因此它们的测定也可能对治疗评估有用。

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