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首页> 外文期刊>Cornea >Expression of CXCL9, -10, and -11 in the aqueous humor of patients with herpetic endotheliitis
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Expression of CXCL9, -10, and -11 in the aqueous humor of patients with herpetic endotheliitis

机译：CXCL9，-10和-11在疱疹性内皮炎患者房水中的表达

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摘要

PURPOSE:: To evaluate the expression of CXCL9, -10, and -11 chemokines in the aqueous humor of patients with herpetic endotheliitis. METHODS:: Aqueous humor was collected from 26 patients with herpetic endotheliitis and 21 control subjects. The concentrations of CXCL9, -10, and -11 in the aqueous humor were measured with enzyme-linked immunosorbent assays. The correlation between chemokine levels and clinical parameters of disease severity was analyzed. Flow cytometry was performed to count CXCR3 cells and CXCR3CD4 cells in the aqueous humor. RESULTS:: The concentrations of CXCL9, -10, and -11 were 429.08 ± 297.41 pg/mL, 23,102.49 ± 15,964.95 pg/mL, and 258.25 ± 103.25 pg/mL in patients with herpetic endotheliitis and 16.84 ± 16.73 pg/mL (P < 0.01), 188.45 ± 183.43 pg/mL (P < 0.01), and 7.32 ± 6.45 pg/mL (P < 0.01) in control subjects, respectively. Aqueous chemokine levels correlated significantly with keratitic precipitates and corneal edema in patients with herpetic endotheliitis. The mean percentages of CXCR3 and CXCR3CD4 cells were higher in herpetic endotheliitis patients compared with the controls. CONCLUSIONS:: Expression of CXCL9, -10, and -11 chemokines and their receptor CXCR3 increases in the aqueous humor of patients with herpetic endotheliitis. Chemokine levels are associated with the clinical severity of the disease.
机译：目的：评估疱疹性内皮炎患者房水中CXCL9，-10和-11趋化因子的表达。方法：从26名疱疹性内皮炎患者和21名对照受试者中收集房水。用酶联免疫吸附测定法测量房水中CXCL9，-10和-11的浓度。分析了趋化因子水平与疾病严重程度的临床参数之间的相关性。进行流式细胞术以计数房水中的CXCR3细胞和CXCR3CD4细胞。结果：疱疹性内皮炎患者的CXCL9，-10和-11的浓度分别为429.08±297.41 pg / mL，23,102.49±15,964.95 pg / mL和258.25±103.25 pg / mL，以及16.84±16.73 pg / mL（P <0.01），188.45±183.43 pg / mL（P <0.01）和7.32±6.45 pg / mL（P <0.01）。疱疹性内皮炎患者的趋化因子水含量与角质形成沉淀物和角膜水肿显着相关。与对照组相比，疱疹性内皮炎患者中CXCR3和CXCR3CD4细胞的平均百分比更高。结论：疱疹性内皮炎患者的房水中CXCL9，-10和-11趋化因子及其受体CXCR3的表达增加。趋化因子水平与疾病的临床严重程度有关。

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