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Indirect comparison in evaluating relative efficacy illustrated by antimicrobial prophylaxis in colorectal surgery.

机译：在结肠直肠手术中通过抗菌药物预防说明相对疗效的间接比较。

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This paper aims to explore the potential usefulness and limitations of indirect comparisons in evaluating the relative efficacy of interventions. From a systematic review of antimicrobial prophylaxis in colorectal surgery, we identified 11 sets of randomized trials that can be used to compare antibiotics both directly and indirectly. The discrepancy between the direct and the indirect comparison is defined as the absolute value of difference in log odds ratio. The adjusted indirect comparison has the advantages that the prognostic factors of participants in different trials can be partially taken into account and more uncertainty be incorporated into its result by providing a wider confidence interval. However, considerable discrepancies exist between the direct and the adjusted indirect comparisons. When there is no direct comparison, the adjusted indirect method may be used to obtain some evidence about the relative efficacy of competing interventions, although such indirect results should be interpreted with great caution. Further empirical and methodologic research is needed to explore the validity and generalizability of the adjusted indirect comparison for evaluating different interventions.
机译：本文旨在探讨间接比较在评估干预措施相对疗效方面的潜在用途和局限性。通过对结直肠手术中抗菌药物预防的系统评价，我们确定了11套可用于直接和间接比较抗生素的随机试验。直接和间接比较之间的差异定义为对数优势比之差的绝对值。调整后的间接比较的优点是可以部分考虑不同试验参与者的预后因素，并通过提供更大的置信区间将更多不确定性纳入其结果。但是，直接比较与调整后的间接比较之间存在相当大的差异。如果没有直接比较，可以使用调整后的间接方法获得有关竞争性干预措施相对疗效的一些证据，尽管对此类间接结果的解释应格外谨慎。需要进行进一步的经验和方法学研究，以探讨调整后的间接比较用于评估不同干预措施的有效性和普遍性。

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