Facile, diastereoselective synthesis of functionally enriched hexahydroisoquinolines, hexahydroisoquinolones and hexahydroisochromones via inter-/intramolecular amidolysis of C-3 functionalized 2-azetidinones

Mehra V.; Kumar V.

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Facile, diastereoselective synthesis of functionally enriched hexahydroisoquinolines, hexahydroisoquinolones and hexahydroisochromones via inter-/intramolecular amidolysis of C-3 functionalized 2-azetidinones

机译：通过C-3功能化的2-氮杂环丁酮的分子间/分子间酰胺分解，轻松，非对映选择性地合成功能丰富的六氢异喹啉，六氢异喹啉酮和六氢异色酮

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We describe herein the synthetic utility of β-lactam synthon protocol for the convenient and diastereoselective synthesis of functionally decorated hexahydroisoquinolines, hexahydroisoquinolones and hexahydroisochromones. Since the described protocol does not include the use of highly functionalized intermediates, stringent conditions or toxic reagents, the developed methodology does not suffer from the typical intricacies associated with the conventional protocols.

机译：我们在本文中描述了β-内酰胺合成子方案的合成效用，用于功能修饰的六氢异喹啉，六氢异喹啉酮和六氢异色酮的方便和非对映选择性合成。由于所述方案不包括使用高度官能化的中间体，严格条件或有毒试剂，因此开发的方法不会遭受与常规方案相关的典型复杂性的困扰。

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《Tetrahedron》 |2013年第19期|共10页
作者
Mehra V.; Kumar V.;
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正文语种 eng
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β-Lactam synthon approach; amidolysis-cyclization; Hexahydroisoquinolines; Hexahydroisoquinolones/hexahydroisochromones; Inter-/intramolecular amidolysis; Tandem intermolecular;

机译：β-内酰胺合成法;酰胺化环化;六氢异喹啉;六氢异喹啉酮/六氢异色酮;分子间/分子间酰胺分解;串联分子间;

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机译：通过C-3功能化的2-氮杂环丁酮的分子间/分子间酰胺分解，轻松，非对映选择性地合成功能丰富的六氢异喹啉，六氢异喹啉酮和六氢异色酮
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Facile, diastereoselective synthesis of functionally enriched hexahydroisoquinolines, hexahydroisoquinolones and hexahydroisochromones via inter-/intramolecular amidolysis of C-3 functionalized 2-azetidinones

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