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首页> 外文期刊>Current Biology: CB >A Role for Vasa in Regulating Mitotic Chromosome Condensation in Drosophila
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A Role for Vasa in Regulating Mitotic Chromosome Condensation in Drosophila

机译：瓦萨在果蝇中调节有丝分裂染色体浓缩中的作用。

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Vasa (Vas) is a conserved DEAD-box RNA helicase expressed in germline cells [1] that localizes to a characteristic perinuclear structure called nuage [[2] and [3]]. Previous studies have shown that Vas has diverse functions, with roles in regulating mRNA translation, germline differentiation, pole plasm assembly, and piwi-interacting RNA (piRNA)-mediated transposon silencing [[1], [4], [5], [6], [7], [8], [9] and [10]]. Although vas has also been implicated in the regulation of germline proliferation in Drosophila and mice [[1] and [11]], little is known about whether Vas plays a role during the mitotic cell cycle. Here, we report a translation-independent function of vas in regulating mitotic chromosome condensation in the Drosophila germline. During mitosis, Vas facilitates robust chromosomal localization of the condensin I components Barren (Barr) and CAP-D2. Vas specifically associates with Barr and CAP-D2, but not with CAP-D3 (a condensin II component). The mitotic function of Vas is mediated by the formation of perichromosomal Vas bodies during mitosis, which requires the piRNA pathway components aubergine and spindle-E. Our results suggest that Vas functions during mitosis and may link the piRNA pathway to mitotic chromosome condensation in Drosophila. Highlights: vasa promotes mitotic chromosome condensation vasa facilitates robust chromosome localization of Barren during mitosis Vasa forms perichromosomal foci during mitosis and interacts with Barren aub and spn-E regulate mitotic Vasa localization and chromosome condensation
机译：Vasa（Vas）是在种系细胞中表达的保守DEAD-box RNA解旋酶[1]，其定位于称为nuage的特征性核周结构[[2]和[3]]。以前的研究表明，Vas具有多种功能，在调节mRNA翻译，种系分化，极质组装和piwi相互作用RNA（piRNA）介导的转座子沉默中发挥作用[[1]，[4]，[5]，[ 6]，[7]，[8]，[9]和[10]。尽管在果蝇和小鼠中，输精管也参与了生殖细胞增殖的调控[[1]和[11]]，但是关于Vas在有丝分裂细胞周期中是否起作用的了解甚少。在这里，我们报告果蝇在调节果蝇种系中的有丝分裂染色体浓缩中的翻译独立功能。在有丝分裂期间，Vas促进了凝集素I组分Barren（Barr）和CAP-D2的稳健的染色体定位。 Vas与Barr和CAP-D2特别相关，但与CAP-D3（凝缩蛋白II成分）无关。 Vas的有丝分裂功能由有丝分裂期间染色体周围Vas体的形成介导，这需要piRNA途径成分茄子和纺锤体E。我们的结果表明，Vas在有丝分裂过程中发挥功能，并可能将piRNA途径与果蝇的有丝分裂染色体凝聚联系起来。亮点：vasa促进有丝分裂染色体凝缩vasa在有丝分裂期间促进贫瘠的牢固染色体定位Vasa在有丝分裂期间形成染色体周围的病灶并与Barren aub和spn-E相互作用调节有丝分裂Vasa定位和染色体凝缩

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