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首页> 外文期刊>Current Biology: CB >Zygotic Resetting of the HISTONE 3 Variant Repertoire Participates in Epigenetic Reprogramming in Arabidopsis
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Zygotic Resetting of the HISTONE 3 Variant Repertoire Participates in Epigenetic Reprogramming in Arabidopsis

机译：HISTONE 3变异库的合子复位参与拟南芥的表观遗传重编程。

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摘要

In most eukaryotes, the HISTONE 3 family comprises several variants distinguished by their amino acid sequence, localization, and correlation with transcriptional activity [1-3]. Transgenerational inheritance of epigenetic information carried by histones is still unclear [4, 5]. In addition to covalent histone modifications, the mosaic distribution of H3 variants onto chromatin has been proposed to provide a new level of epigenetic information [6]. To study the transmission of patterns of H3 variants through generations, we combined transcriptional profiling and live imaging of the 13 H3 variants encoded by the Arabidopsis plant genome [7]. In comparison with somatic cells, only a restricted number of H3 variants are present in male and female gametes. Upon fertilization, H3 variants contributed by both gametes are actively removed from the zygote chromatin. The somatic H3 composition is restored in the embryo by de novo synthesis of H3 variants. A survey of Arabidopsis homologs of animal H3 chaperones suggests that removal of parental H3 from the zygote nucleus relies on a new mechanism. Our results suggest that reprogramming of parental genomes in the zygote limits the inheritance of epigenetic information carried by H3 variants across generations.
机译：在大多数真核生物中，HISTONE 3家族包含几个变异体，这些变异体的氨基酸序列，定位以及与转录活性的相关性[1-3]。组蛋白携带的表观遗传信息的跨代遗传尚不清楚[4，5]。除共价组蛋白修饰外，还提出了将H3变异体镶嵌在染色质上的方法，以提供更高水平的表观遗传信息[6]。为了研究H3变体模式的世代传播，我们结合了拟南芥植物基因组编码的13个H3变体的转录谱和实时成像[7]。与体细胞相比，雄配子和雌配子中仅存在有限数量的H3变体。受精后，由两种配子贡献的H3变体从合子染色质中被主动去除。通过从头合成H3变异体，可以恢复胚胎中的H3体细胞组成。对动物H3分子伴侣的拟南芥同源物的调查表明，从合子核中去除亲本H3依赖于一种新的机制。我们的结果表明，合子中父母基因组的重编程限制了H3变异体跨代携带的表观遗传信息的遗传。

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