...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Vaccine >Rotavirus vaccination effectiveness: a case-case study in the EDICS project, Castellon (Spain).
【24h】

Rotavirus vaccination effectiveness: a case-case study in the EDICS project, Castellon (Spain).

机译：轮状病毒疫苗接种的有效性：西班牙Castellon EDICS项目中的案例研究。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In Spain, in 2006, two oral live-attenuated vaccines against rotavirus disease were licensed for infants up to 6 months. Recent data suggest that vaccine efficacy may vary by region. This makes the real-life postmarketing monitoring of rotavirus vaccination effectiveness an important aspect of rotavirus epidemiologic surveillance. We carried out a case-case study to assess the rotavirus vaccination effectiveness in children from 2 to 35 months of age during the year 2009 in Castellon. As a second- and counterfactual objective to evaluate the possible selection bias and the specificity of the association, we evaluated the "effectiveness" of pneumococcal vaccination against rotavirus diarrhea. Cases were 71 children with confirmed rotavirus gastroenteritis, and controls were 261 children with positive results to any other organism that was not rotavirus. The immunization status of each child, the number of doses and dates of vaccination were assessed by consulting the Regional Immunization Registry. The lowest proportion of vaccinated cases was observed among rotavirus diarrhea (2.8%). The proportion of vaccinated children among the control group was 21.8%. The effectiveness of vaccination with at least one dose of vaccine against rotavirus was 87.7% (45.5-99.7%). If we restrict the analysis to non-hospitalized children, this figure was slightly lower, 83.5% (25.4-96.3%). As expected, pneumococcal vaccination was not protective against rotavirus infection showing the specificity of the association found. The immunization information systems in combination with population-based studies of the incidence of infectious gastroenteritis, such as EDICS offer appropriate conditions for postmarketing monitoring of vaccine effectiveness.
机译：2006年，西班牙在西班牙批准了两种针对轮状病毒疾病的口服减毒活疫苗，适用于6个月以下的婴儿。最新数据表明，疫苗效力可能因地区而异。这使得轮状病毒疫苗接种效果的现实生活售后监测成为轮状病毒流行病学监测的重要方面。我们进行了个案研究，以评估2009年Castellon地区2到35个月大的儿童中轮状病毒疫苗接种的有效性。作为评估可能的选择偏差和关联特异性的第二和反事实目标，我们评估了肺炎球菌疫苗接种对轮状病毒腹泻的“有效性”。病例为71例确诊的轮状病毒胃肠炎患儿，对照组为261例对其他非轮状病毒生物体阳性的患儿。每个孩子的免疫状况，剂量和接种日期通过咨询区域免疫登记处进行评估。轮状病毒腹泻中接种疫苗的比例最低（2.8％）。对照组中接种疫苗的儿童比例为21.8％。至少接种一剂针对轮状病毒的疫苗的接种效果为87.7％（45.5-99.7％）。如果我们仅将分析局限于非住院儿童，则该数字略低，为83.5％（25.4-96.3％）。不出所料，肺炎球菌疫苗接种不能预防轮状病毒感染，显示出发现的关联的特异性。免疫信息系统与基于人群的传染性胃肠炎发病率研究（例如EDICS）相结合，为上市后监测疫苗有效性提供了适当的条件。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号