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首页> 外文期刊>Vaccine >A critical analysis of the cynomolgus macaque, Macaca fascicularis, as a model to test HIV-1/SIV vaccine efficacy
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A critical analysis of the cynomolgus macaque, Macaca fascicularis, as a model to test HIV-1/SIV vaccine efficacy

机译：猕猴猕猴的关键分析，作为测试HIV-1 / SIV疫苗功效的模型

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摘要

The use of a number of non-rhesus macaque species, but especially cynomolgus macaques as a model for HIV-1 vaccine development has increased in recent years. Cynomolgus macaques have been used in the United Kingdom, Europe, Canada and Australia as a model for HIV vaccine development for many years. Unlike rhesus macaques, cynomolgus macaques infected with SIV show a pattern of disease pathogenesis that more closely resembles that of human HIV-1 infection, exhibiting lower peak and set-point viral loads and slower progression to disease with more typical AIDS defining illnesses. Several advances have been made recently in the use of the cynomolgus macaque SIV challenge model that allow the demonstration of vaccine efficacy using attenuated viruses and vectors that are both viral and non-viral in origin. This review aims to probe the details of various vaccination trials carried out in cynomolgus macaques in the context of our modern understanding of the highly diverse immunogenetics of this species with a view to understanding the species-specific immune correlates of protection and the efficacy of vectors that have been used to design vaccines. (C) 2015 Published by Elsevier Ltd.
机译：近年来，越来越多的非猕猴（尤其是食蟹猕猴）被用作开发HIV-1疫苗的模型。食蟹猕猴已在英国，欧洲，加拿大和澳大利亚用作艾滋病毒疫苗开发的模型多年。与猕猴不同，感染SIV的食蟹猕猴显示出一种更类似于人类HIV-1感染的疾病发病机理，表现出较低的峰值病毒和设定点病毒载量，并且病情发展较慢，具有更多典型的AIDS定义的疾病。食蟹猕猴SIV攻击模型的使用最近取得了一些进展，这些模型允许使用源于病毒和非病毒的减毒病毒和载体来证明疫苗效力。这篇综述旨在探讨食蟹猕猴在我们对该物种高度多样的免疫遗传学的现代理解的背景下进行的各种疫苗接种试验的细节，以期了解保护的物种特异性免疫相关性以及载体的功效，已经被用来设计疫苗。 （C）2015由Elsevier Ltd.出版

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