Cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives for mitochondrial imaging in living cells

Jin Chengzhi; Liu Jiangping; Chen Yu; Li Guanying; Guan Ruilin; Zhang Pingyu; Ji Liangnian; Chao Hui

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Cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives for mitochondrial imaging in living cells

机译：咪唑并[4,5-f] [1,10]菲咯啉衍生物的环金属化铱（III）配合物在活细胞中的线粒体成像

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A new series of cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10] phenanthroline derivatives (i.e., Mitolr1-Mitolr7) were synthesized and developed to image mitochondria in living cells. In comparison with commercially available mitochondrial trackers, these complexes exhibit a superior capacity to selectively accumulate in mitochondria with no requirement of any membrane permeabilization or replacement of the culture medium. In addition, the excellent photostability under continuous laser irradiation as well as the stable physiological pH resistance of these complexes were confirmed by photobleaching experiments and luminescence measurements. Importantly, Mitolr7, which exhibited both excellent luminescence and high ability to locate in mitochondria, was developed to track the mitochondrial morphological changes over a long period of time.

机译：合成了一系列新的具有咪唑并[4,5-f] [1,10]菲咯啉衍生物的环金属化铱（III）配合物（即Mitolr1-Mitolr7），并将其显影以成像活细胞中的线粒体。与市售的线粒体追踪剂相比，这些复合物表现出优异的选择性积聚在线粒体中的能力，而无需任何膜透化或更换培养基。此外，通过光漂白实验和发光测量证实了这些配合物在连续激光照射下的优异光稳定性以及稳定的生理pH抗性。重要的是，开发了Mitolr7，它既具有出色的发光性能，又具有高定位线粒体的能力，因此可以长期跟踪线粒体的形态变化。

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《Dalton transactions: An international journal of inorganic chemistry》 |2015年第16期|共10页
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Jin Chengzhi; Liu Jiangping; Chen Yu; Li Guanying; Guan Ruilin; Zhang Pingyu; Ji Liangnian; Chao Hui;
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1. Cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives for mitochondrial imaging in living cells [J] . Jin Chengzhi, Liu Jiangping, Chen Yu, Dalton transactions: An international journal of inorganic chemistry . 2015,第16期

机译：咪唑并[4,5-f] [1,10]菲咯啉衍生物的环金属化铱（III）配合物在活细胞中的线粒体成像
2. Syntheses, spectroscopic and crystal structural studies of novel imidazo [4,5-f]1,10-phenanthroline derivatives and their Eu(III) ternary complexes with dibenzoylmethane [J] . Bian ZQ., Wang KZ., Jin LP. Polyhedron: The International Journal for Inorganic and Organometallic Chemistry . 2002,第3期

机译：新型咪唑并[4,5-f] 1,10-菲咯啉衍生物及其与二苯甲酰甲烷的Eu（III）三元配合物的合成，光谱和晶体结构研究
3. DNA-interactions of ruthenium(II) & cobalt(III) phenanthroline and bipyridine complexes with a planar aromatic ligand 2-(2-fluronyl)1H-imidazo[4,5-f][1,10-Phenanthroline] [J] . Mynam Shilpa, J. Naveena Lavanya Latha, A. Gayatri Devi Journal of Inclusion Phenomena and Macrocyclic Chemistry . 2011,第1a2期

机译：钌（II）和钴（III）菲咯啉和联吡啶配合物与平面芳香族配体2-（2-氟酰基）1H-咪唑并[4,5-f] [1,10-菲咯啉]的相互作用
4. Synthesis , Characterization and Photophysical Properties of a new Cu~1 Complexe contain Bis2-(diphenylphosphino)phenyiether and 2-(anthracen-9-yl)-1 -phenyl-1H-imidazo4,5-f1,10phenanthroline [C] . Jiling He International Conference on Chemical Engineering and Advanced Materials . 2014

机译：新Cu〜1复合物的合成，表征和光物理性质含有双2-（二苯基膦基）酚乙醚和2-（蒽-9-基）-1-苯基-1H-咪唑4,5-F 1,10菲咯啉
5. The Luminescent Properties of Europium Thenoyltrifluoroacetone Complexes with 2-Phenyl-1h-Imidazo[4,5-f][1,10]Phenanthroline Based Ligands [D] . Venturo, Paul Jacob. 2020

机译：铕的发光特性罗霉氟丙酮配合物用2-苯基-1H-咪唑络合物[4,5-F] [1,10]菲芳啉基配体
6. Cyclometalated Iridium(III) Complexes as AIE Phosphorescent Probes for Real-Time Monitoring of Mitophagy in Living Cells [O] . Chengzhi Jin, Jiangping Liu, Yu Chen, -1

机译：环金属化铱（III）络合物作为AIE磷光探针用于实时监测活细胞中的线粒体
7. Cyclometalated Iridium(III) Complexes as AIE Phosphorescent Probes for Real-Time Monitoring of Mitophagy in Living Cells [O] . Chengzhi Jin, Jiangping Liu, Yu Chen, 2016

机译：环状氧化铱（III）复合物作为AIE磷光探针，用于实时监测活细胞中的水墨

Cyclometalated iridium(III) complexes with imidazo[4,5-f][1,10]phenanthroline derivatives for mitochondrial imaging in living cells

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