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首页> 外文期刊>Current Biology: CB >Embryonic cleavage cycles: How is a mouse like a fly? [Review]
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Embryonic cleavage cycles: How is a mouse like a fly? [Review]

机译：胚胎卵裂周期：老鼠像苍蝇怎么样？ [评论]

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摘要

The evolutionary advent of uterine support of embryonic growth in mammals is relatively recent. Nonetheless, striking differences in the earliest steps of embryogenesis make it difficult to draw parallels even with other chordates. We suggest that use of fertilization as a reference point misaligns the earliest stages and masks parallels that are evident when development is aligned at conserved stages surrounding gastrulation. In externally deposited eggs from representatives of all the major phyla, gastrulation is preceded by specialized extremely rapid cleavage cell cycles. Mammals also exhibit remarkably fast cell cycles in close association with gastrulation, but instead of beginning development with these rapid cycles, the mammalian egg first devotes itself to the production of extraembryonic structures. Previous attempts to identify common features of cleavage cycles focused on post-fertilization divisions of the mammalian egg. We propose that comparison to the rapid peri-gastrulation cycles is more appropriate and suggest that these cycles are related by evolutionary descent to the early cleavage stages of embryos such as those of frog and fly. The deferral of events in mammalian embryogenesis might be due to an evolutionary shift in the timing of fertilization.
机译：哺乳动物对胚胎生长的子宫支持的进化出现是相对较新的。但是，在胚胎发生的最早步骤中存在显着差异，即使与其他弦乐也很难相提并论。我们建议使用受精作为参考点会错位最早的阶段，并掩盖平行性，这在围绕胃芽肥的保守阶段进行发育对齐时很明显。在来自所有主要门的代表的外部沉积卵中，在胃形成器官之前发生专门的极其迅速的裂解细胞周期。哺乳动物还表现出与胃造血紧密相关的非常快速的细胞周期，但是哺乳动物卵首先致力于生产胚外结构，而不是以这些快速周期开始发育。先前鉴定卵裂周期共同特征的尝试集中于哺乳动物卵的受精后分裂。我们提出，与快速围胃周期比较是更合适的，并建议这些周期通过进化下降与胚胎的早期分裂阶段相关，例如青蛙和苍蝇。哺乳动物胚胎发生事件的推迟可能是由于受精时间的演变所致。

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