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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Differential Inhibitory Effects of Conjugated Linoleic Acid Isomers on Mouse Forestomach Neoplasia Induced by Benzo(a)pyrene
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Differential Inhibitory Effects of Conjugated Linoleic Acid Isomers on Mouse Forestomach Neoplasia Induced by Benzo(a)pyrene

机译：共轭亚油酸异构体对苯并（a）py诱导的小鼠前胃瘤形成的差异抑制作用

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摘要

The differential anticarcinogenic activity of conjugated linoleic acid (CLA) isomers, including c9,t11-CLA, t10,c12-CLA, and t,t-CLA, was examined in a mouse forestomach carcinogenesis regimen induced by benzo(a)pyrene (BP). Female ICR mice (6-7 weeks of age, 26 ± 1 g) were divided into six groups (30 mice/group, 5 mice/cage): control, linoleic acid, CLA, c9,t11-CLA, t10,c12-CLA, and t, t-CLA. Each mouse was orally given 0.1 mL of sample and 0.1 mL of olive oil on Monday and Wednesday and BP (2 mg in 0.2 mL of olive oil) on Friday. This cycle was repeated four times. Twenty-three weeks later, the experiment was terminated for tumor analysis. t,t-CLA significantly reduced (p < 0.05) both tumor number and tumor size per mouse, relative to CLA and c9,t11-CLA, but similar to t10,c12-CLA. Reduction in tumor incidence by t,t-CLA (84.6%) was similar to that by CLA, c9,t11-CLA, and t10,c12-CLA, but it was significantly reduced (p < 0.05), relative to 100% linoleic acid and control. t,t-CLA elevated the apoptotic index to 35%, relative to 23% for CLA, 21% for c9,t11-CLA, 29% for t10,c12-CLA, 7% for linoleic acid, and 4% for control. t,t-CLA up-regulated the expression of the Bax gene and activated caspase-3 enzymes but down-regulated expression of the Bcl-2 gene. Cytosolic phospholipase A2 activity was not affected by the CLA isomers tested. These results suggest that t,t-CLA has superior anticarcinogenic potential on BP-induced mouse forestomach neoplasia to CLA, c9,t11-CLA, and t10,c12-CLA, via the induction of apoptosis through mitochondrial dysfunction.
机译：共轭亚油酸（CLA）异构体（包括c9，t11-CLA，t10，c12-CLA和t，t-CLA）的不同抗癌活性在苯并（a）py（BP）诱导的小鼠前胃癌致癌方案中进行了研究）。将ICR雌性小鼠（6-7周龄，26±1 g）分成六组（每组30只小鼠，每只笼5只小鼠）：对照组，亚油酸，CLA，c9，t11-CLA，t10，c12- CLA和t，t-CLA。在周一和周三给每只小鼠口服0.1 mL样品和0.1 mL橄榄油，在周五给BP（2 mg在0.2 mL橄榄油中）口服。该循环重复四次。 23周后，实验被终止以进行肿瘤分析。相对于CLA和c9，t11-CLA，t，t-CLA显着降低了每只小鼠的肿瘤数量和肿瘤大小（p <0.05），但与t10，c12-CLA相似。 t，t-CLA（84.6％）的肿瘤发生率降低与CLA，c9，t11-CLA和t10，c12-CLA相似，但相对于100％的亚油酸，其显着降低（p <0.05）酸和控制。 t，t-CLA将细胞凋亡指数提高到35％，相对于CLA为23％，c9，t11-CLA为21％，t10，c12-CLA为29％，亚油酸为7％，对照为4％。 t，t-CLA上调了Bax基因的表达和激活的caspase-3酶，但下调了Bcl-2基因的表达。胞质磷脂酶A2活性不受所测试的CLA异构体的影响。这些结果表明，t，t-CLA通过线粒体功能障碍诱导细胞凋亡，对BP诱导的小鼠前胃瘤形成具有比CLA，c9，t11-CLA和t10，c12-CLA更高的抗癌潜力。

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