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首页> 外文期刊>Journal of Agricultural and Food Chemistry >Dietary Intake of Melatonin from Tropical Fruit Altered Urinary Excretion of 6-Sulfatoxymelatonin in Healthy Volunteers
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Dietary Intake of Melatonin from Tropical Fruit Altered Urinary Excretion of 6-Sulfatoxymelatonin in Healthy Volunteers

机译：饮食中热带水果中褪黑激素的摄入改变了健康志愿者尿中6-巯基氧基褪黑素的排泄量。

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摘要

This study assessed the melatonin content of six tropical fruits and examined whether human consumption could contribute to dietary melatonin as measured by 6-sulfatoxymelatonin (aMT6-s, a marker of circulating melatonin in the body). Melatonin was extracted using methanol and analyzed by high-performance liquid chromatography. In a clinical crossover study, 30 healthy volunteers consumed selected fruits one at a time, with a lweek wash-out period between fruits, until completing all six fruits. Most fruits had moderate melatonin content. Significant increases in urine aMT6-s concentrations were seen after the consumption of pineapple (266%, p - 0.004), banana (180%, p = 0.001), and orange (47%, p ~ 0.007). The need to analyze melatonin both in fruit and as in vivo uptake was demonstrated. Further study is warranted regarding the clinical effect of fruit consumption in people with age-related melatonin reduction problems such as sleeplessness and illnesses involving oxidative damage.
机译：这项研究评估了6种热带水果中的褪黑激素含量，并通过6-巯基氧基褪黑激素（aMT6-s，体内循环褪黑激素的标志物）测定了人类食用是否能促进饮食中的褪黑激素。使用甲醇提取褪黑激素，并通过高效液相色谱法进行分析。在一项临床交叉研究中，30名健康志愿者一次食用了一个选定的水果，每个水果之间有1周的清除期，直到完成所有六个水果。大多数水果的褪黑激素含量适中。食用菠萝（266％，p-0.004），香蕉（180％，p = 0.001）和橘子（47％，p〜0.007）后，尿aMT6-s浓度显着增加。已证明需要分析水果和体内摄取的褪黑激素。需要进行进一步的研究，以研究与年龄相关的褪黑激素减少问题（例如失眠和涉及氧化损伤的疾病）的人食用水果的临床效果。

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