Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo

Huarong Huang; Yan He; Xiao-Xing Cui

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Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo

机译：δ-生育酚对体外培养和体内异种移植瘤生长的前列腺癌细胞的强抑制作用

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In the present study, the effects of δ-tocopherol (δ-T) on growth and apoptosis of human prostate cancer cells were determined and compared with that of a-tocopherol (α-T), a commonly used form of vitamin E. Treatment of human prostate cancer cells with δ-T resulted in strong growth inhibition and apoptosis stimulation, while the effects of a-T were modest. The strong effects of δ-T on the cells were associated with suppression of androgen receptor (AR) activity and decreased level of prostate specific antigen (PSA) that is a downstream target of the AR signaling. In the in vivo study, we found that δ-T had a more potent inhibitory effect on the formation and growth of prostate xenograft tumors than that of a-T. Moreover, δ-T inhibited proliferation and stimulated apoptosis in the tumors. The present study identified 5-T as a better form of vitamin E than a-T for future clinical studies of prostate cancer prevention.

机译：在本研究中，确定了δ-生育酚（δ-T）对人前列腺癌细胞生长和凋亡的影响，并将其与维生素E的常用形式a-生育酚（α-T）进行了比较。 δ-T对人前列腺癌细胞的抑制导致强烈的生长抑制和细胞凋亡刺激，而aT的影响却不大。 δ-T对细胞的强大作用与抑制雄激素受体（AR）活性和降低前列腺特异抗原（PSA）的水平有关，后者是AR信号的下游靶标。在体内研究中，我们发现δ-T比a-T对前列腺异种移植肿瘤的形成和生长具有更强的抑制作用。而且，δ-T抑制肿瘤中的增殖并刺激细胞凋亡。本研究确定了5-T比a-T更好的维生素E形式，可用于未来预防前列腺癌的临床研究。

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《Journal of Agricultural and Food Chemistry》 |2014年第44期|共7页
作者
Huarong Huang; Yan He; Xiao-Xing Cui;
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正文语种 eng
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prostate cancer; vitamin E; tocopherol; apoptosis; AR signaling; xenograft tumor;

机译：前列腺癌;维生素E;生育酚;凋亡;AR信号传导;异种移植瘤;

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1. Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo [J] . Huarong Huang, Yan He, Xiao-Xing Cui Journal of Agricultural and Food Chemistry . 2014,第44期

机译：δ-生育酚对体外培养和体内异种移植瘤生长的前列腺癌细胞的强抑制作用
2. Penta-1,2,3,4,6-O-galloyl-beta-D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo. [J] . Hu H, Lee HJ, Jiang C, Molecular cancer therapeutics . 2008,第9期

机译：Penta-1,2,3,4,6-O-galloyl-β-D-葡萄糖在体外可诱导前列腺癌细胞中的p53并抑制STAT3，并在体内抑制前列腺异种移植瘤的生长。
3. Potent inhibitory effect of terpenoids from Acanthopanax trifoliatus on growth of PC-3 prostate cancer cells in vitro and in vivo is associated with suppression of NF-kappa B and STAT3 signalling [J] . Li Dongli, Du Zhiyun, Li Chenyue, Journal of Functional Foods . 2015,第Null期

机译：刺五加的萜类化合物在体外和体内对PC-3前列腺癌细胞生长的强抑制作用与抑制NF-κB和STAT3信号传导有关
4. Design, Synthesis, Biophysical and Structure-Activity Properties of a Novel Dual MDM2 and MDMX Targeting Stapled α-Helical Peptide: ATSP-7041 Exhibits Potent In Vitro and In Vivo Efficacy in Xenograft Models of Human Cancer [C] . V. Guerlavais, K. Darlak, B. Graves American Peptide Symposium . 2013

机译：新型双MDM2和MDMX靶向吻合α-螺旋肽的设计，合成，生物物理和结构 - 活性特性：ATSP-7041在体外表现出效率和体内人类癌症的模型
5. Antiproliferative effects of isoflavonoids on prostate cancer cells and antitumorigenic effects in xenograft nude mice. [D] . Samedi, Von Graeger. 2001

机译：异黄酮类化合物对前列腺癌细胞的抗增殖作用和异种移植裸鼠的抗肿瘤作用。
6. PotentInhibitory Effect of δ-Tocopherolon Prostate Cancer Cells Cultured in Vitro and Grown As XenograftTumors in Vivo [O] . Huarong Huang, ⊥, Yan He, -1

机译：有力δ-生育酚的抑制作用体外培养和异种移植生长的前列腺癌细胞研究体内肿瘤
7. Penta-1,2,3,4,6-O-galloyl- -D-glucose induces p53 and inhibits STAT3 in prostate cancer cells in vitro and suppresses prostate xenograft tumor growth in vivo [O] . H. Hu, H.-J. Lee, C. Jiang, 2008

机译：Penta-1,2,3,4,4,6- o-galloyl--d-葡萄糖诱导p53并在体外抑制前列腺癌细胞中的stat3，抑制了体内前列腺异种移植肿瘤生长

Potent Inhibitory Effect of δ-Tocopherol on Prostate Cancer Cells Cultured in Vitro and Grown As Xenograft Tumors in Vivo

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