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首页> 外文期刊>Journal of Applied Polymer Science >Copolymers of unsaturated and saturated poly(ether ester amide)s: Synthesis, characterization, and biodegradation
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Copolymers of unsaturated and saturated poly(ether ester amide)s: Synthesis, characterization, and biodegradation

机译：不饱和和饱和聚醚醚酰胺的共聚物：合成，表征和生物降解

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A series of biodegradable random unsaturated/saturated poly(ether ester amide)s copolymers (USPEEAs) were synthesized by an active solution polycondensation of unsaturated and saturated dicarboxylic acid-based diester monomers with diamine salts of phenylalanine and saturated oligo(ethylene glycol) (OEG). These USPEEA copolymers were obtained with fairly good yields in DMA solvent. The chemical structures of the USPEEA copolymers were confirmed by both IR and NMR spectra. The molecular weights (M-n and M-w) of USPEEAs measured by GPC ranged from 3 to 27 kg/mol with the molecular weight distribution (MWD) ranging from 1.52 to 2.13. USPEEA copolymers obtained had T, lower than that of the pure UPEEAs but higher than that of pure saturated poly(ether ester amide)s (SPEEA). An increase in the unsaturated component in USPEEAs led to an increase in their T-g. A preliminary in vitro biodegradation property of USPEEA copolymers were investigated in both pure PBS buffer and alpha-chymotrypsin solutions. The USPEEA copolymers showed a pronounced weight loss in enzyme solutions, but a smaller weight loss in a pure PBS. The biodegradation rates of USPEEA copolymers in of-chymotrypsin solution were much slower than those of pure PEEAs. Therefore, upon adjusting monomers feed ratio, USPEEA copolymers could have controlled chemical, physical, and biodegradation properties. (C) 2008 Wiley Periodicals, Inc.
机译：通过不饱和和饱和二羧酸基二酯单体与苯丙氨酸和饱和低聚乙二醇（OEG）的二胺盐的活性溶液缩聚反应，合成了一系列可生物降解的无规不饱和/饱和聚醚醚酰胺酰胺共聚物（USPEEA）。 ）。这些USPEEA共聚物是在DMA溶剂中以相当好的收率获得的。 USPEEA共聚物的化学结构通过IR和NMR光谱确定。通过GPC测量的USPEEA的分子量（M-n和M-w）为3至27 kg / mol，分子量分布（MWD）为1.52至2.13。获得的USPEEA共聚物的T值低于纯UPEEA的T，但高于纯饱和聚醚醚酰胺（SPEEA）的T。 USPEEA中不饱和成分的增加导致其T-g的增加。在纯PBS缓冲液和α-胰凝乳蛋白酶溶液中均研究了USPEEA共聚物的初步体外生物降解性能。 USPEEA共聚物在酶溶液中显示出明显的重量损失，但在纯PBS中显示出较小的重量损失。 USPEEA共聚物在胰凝乳蛋白酶溶液中的生物降解速度要比纯PEEA慢得多。因此，通过调节单体的进料比例，USPEEA共聚物可以控制化学，物理和生物降解性能。 （C）2008 Wiley期刊公司

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