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首页> 外文期刊>Journal of Applied Polymer Science >Isothermal kinetics of (E)-4-(4-Metoxyphenyl)-4-oxo-2-butenoic acid release from a poly(acrylic acid-co-methacrylic acid) hydrogel
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Isothermal kinetics of (E)-4-(4-Metoxyphenyl)-4-oxo-2-butenoic acid release from a poly(acrylic acid-co-methacrylic acid) hydrogel

机译：聚（丙烯酸-共-甲基丙烯酸）水凝胶释放（E）-4-（4-甲氧基苯基）-4-氧代-2-丁烯酸的等温动力学

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摘要

A kinetic study of the release of the drug (E)-4-(4-metoxyphenyl)-4-oxo-2-butenoic acid (MEPBA) from a poly(acrylic acid-co-methacrylic acid) (PAA-co-MA) hydrogel was performed. The isothermal kinetic curves of MEPBA release from the PAA-co-MA hydrogel in bidistilled water at different temperatures ranging from 20 to 40 degrees C were determined. The reaction rate constants of the investigated process were determined with the initial rate, the saturation rate, and Peppas's semiempirical equation. Also, a model-fitting method for the determination of the kinetics model of drug release was applied. The influence of a at the values of the kinetic parameters and the presence of a compensation effect was established. A procedure for the determination of the distribution function of the activation energies was developed. This procedure was based on the experimentally determined relationship between the activation energy and a. The mechanism of active compound release is discussed. (c) 2007 Wiley Periodicals, Inc.
机译：药物（E）-4-（4-甲氧基苯基）-4-氧代-2-丁烯酸（MEPBA）从聚（丙烯酸-共-甲基丙烯酸）（PAA-co-MA）释放的动力学研究进行水凝胶。测定了在20至40摄氏度的不同温度下在双蒸馏水中PAA-co-MA水凝胶释放的MEPBA的等温动力学曲线。研究过程的反应速率常数由初始速率，饱和速率和Peppas的半经验方程式确定。同样，采用了模型拟合方法来确定药物释放动力学模型。确定了α对动力学参数值的影响和补偿作用的存在。开发了确定活化能分布函数的程序。该过程基于活化能与α之间的实验确定的关系。讨论了活性化合物释放的机理。 （c）2007年Wiley Periodicals，Inc.

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