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首页> 外文期刊>Journal of Applied Polymer Science >Synthesis, Characterization and Efficacy of Chemically Crosslinked PVA Hydrogels for Dermal Wound Healing in Experimental Animals
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Synthesis, Characterization and Efficacy of Chemically Crosslinked PVA Hydrogels for Dermal Wound Healing in Experimental Animals

机译：化学交联的PVA水凝胶的合成，表征及在实验动物皮肤伤口愈合中的功效

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In this study, we have investigated the efficacy of crosslinked polyvinyl alcohol (PVA) hydrogel as a wound dressing material, using rat as the animal model. The hydrogel was synthesized by chemical crosslinking of PVA with potassium persulphate and the crosslinking reaction parameters were optimized. The developed hydrogel was found to possess excellent mechanical properties, high water absorption capacity, gel content, and optimum water vapor transmission rate, indicating its ability to act as an effective wound dressing material. The inherent nontoxic characteristics of PVA remained unaltered after crosslinking. The in vitro diffusion studies of bovine serum albumin (BSA) as model protein, indicated a relatively slow release of protein resulting from its microencapsulation in the polymeric matrix. For in vivo studies, full-thickness excision wounds (2 × 2 cm2 ) were made on the dorsal surface of rats. The hydrogel was applied on the wound and changed at regular intervals. For comparison of wound healing ability, a radiation crosslinked PVA-based hydrogel, ‘‘HiZel’’ was used as a reference control. The wounds treated with PVA hydrogel healed faster as indicated by an increased rate of wound contraction (16.5 days versus 22.0 in control group). Treatment with ‘‘Hizel’’ led to increase in hydroxyproline in the wound tissue, whereas treatment with PVA hydrogel led to increase in both hydroxyproline as well as hexosamine. This probably provides added strength to the tissue, thereby indicating that PVA hydrogel had higher efficacy than ‘‘Hizel’’. The results suggest that chemically crosslinked PVA hydrogel could be used as an effective wound dressing material.
机译：在这项研究中，我们使用大鼠作为动物模型，研究了交联聚乙烯醇（PVA）水凝胶作为伤口敷料的功效。通过PVA与过硫酸钾的化学交联合成水凝胶，并优化了交联反应参数。发现开发的水凝胶具有优异的机械性能，高吸水能力，凝胶含量和最佳的水蒸气透过率，表明其具有充当有效伤口敷料的能力。交联后，PVA固有的无毒特性保持不变。牛血清白蛋白（BSA）作为模型蛋白质的体外扩散研究表明，由于蛋白质微囊化在聚合物基质中，蛋白质释放相对缓慢。为了进行体内研究，在大鼠的背侧制作了全层切除伤口（2×2 cm2）。将水凝胶施加在伤口上，并定期更换。为了比较伤口的愈合能力，使用了辐射交联的基于PVA的水凝胶“ HiZel”作为参考对照。 PVA水凝胶治疗的伤口愈合更快，如伤口收缩率增加（16.5天，对照组为22.0天）所示。用“ Hizel”治疗导致伤口组织中羟脯氨酸的增加，而用PVA水凝胶治疗导致羟脯氨酸和己糖胺的增加。这可能会增强组织的强度，从而表明PVA水凝胶比“ Hizel”具有更高的功效。结果表明，化学交联的PVA水凝胶可以用作有效的伤口敷料。

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