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首页> 外文期刊>Journal of Applied Polymer Science >Novel Thermosensitive Hydrogel Composites Based on Poly(D,L-lactide-co-glycolide) Nanoparticles Embedded in Poly(N-isopropyl acrylamide) with Sustained Drug-Release Behavior
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Novel Thermosensitive Hydrogel Composites Based on Poly(D,L-lactide-co-glycolide) Nanoparticles Embedded in Poly(N-isopropyl acrylamide) with Sustained Drug-Release Behavior

机译：基于埋入聚（N-异丙基丙烯酰胺）中的聚（D，L-丙交酯-乙交酯）纳米粒子的新型热敏水凝胶复合材料，具有持续的释药性能

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摘要

To reach sustained drug release, a new composite drug-delivery system consisting of poly(D,L-lactide-co-glycolide) (PLGA) nanoparticles (NPs) embedded in thermosensitive poly(N-isopropyl acrylamide) (PNIPAAm) hydrogels was developed. The PNIPAAm hydrogels were synthesized by free-radical polymerization and were crosslinked with poly(ethylene glycol) diacrylate, and the PLGA NPs were prepared by a water-in-oil-in-water double-emulsion solvent-evaporation method. The release behavior of the composite hydrogels loaded with albumin–fluorescein isothiocyanate conjugate was studied and compared with that of the drug-loaded neat hydrogel and PLGA NPs. The results indicate that we could best control the release rate of the drug by loading it to the PLGA NPs and then embedding the whole system in the PNIPAAm hydrogels. The developed composite hydrogel systems showed near zeroorder drug-release kinetics along with a reduction or omission of initial burst release. The differential scanning calorimetry results reveal that the lower critical solution temperature of the developed composite systems remained almost unchanged (<1℃ increase only). Such a characteristic indicated that the thermosensitivity of the PNIPAAm hydrogel was not distinctively affected by the addition of PLGA NPs. In conclusion, an approach was demonstrated for the successful preparation of a new hybrid hydrogel system having improved drug-release behavior with retained thermosensitivity. The developed systems have enormous potential for many biotechnological applications.
机译：为了达到持续的药物释放，开发了一种新的复合药物递送系统，该系统由嵌入热敏性聚（N-异丙基丙烯酰胺）（PNIPAAm）水凝胶中的聚（D，L-丙交酯-乙交酯）（PLGA）纳米粒子（NP）组成。 PNIPAAm水凝胶通过自由基聚合反应合成，并与聚乙二醇二丙烯酸酯交联，PLGA NPs通过水包油包水双乳液溶剂蒸发法制备。研究了载有白蛋白-荧光素异硫氰酸酯结合物的复合水凝胶的释放行为，并将其与载药的纯净水凝胶和PLGA NPs的释放行为进行了比较。结果表明，我们可以通过将药物加载到PLGA NP中，然后将整个系统嵌入PNIPAAm水凝胶中来最好地控制药物的释放速率。已开发的复合水凝胶系统显示出接近零级的药物释放动力学，以及初始爆发释放的减少或遗漏。差示扫描量热法的结果表明，已开发的复合系统的较低临界溶液温度几乎保持不变（仅增加<1℃）。这样的特性表明PNIPAAm水凝胶的热敏性不受PLGA NPs的添加的显着影响。总之，证明了一种成功制备具有改善的药物释放性能并保留了热敏性的新型混合水凝胶系统的方法。发达的系统对于许多生物技术应用具有巨大的潜力。

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