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首页> 外文期刊>Journal of Applied Polymer Science >Epoxidized poly(N-isopropyl acrylamide)-b-epoHTPB-b-poly(N-isopropyl acrylamide) triblock copolymer micelle nanoparticles for 10-hydroxycamptothecin drug release
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Epoxidized poly(N-isopropyl acrylamide)-b-epoHTPB-b-poly(N-isopropyl acrylamide) triblock copolymer micelle nanoparticles for 10-hydroxycamptothecin drug release

机译：用于10-羟基喜树碱药物释放的环氧化聚（N-异丙基丙烯酰胺）-b-epoHTPB-b-聚（N-异丙基丙烯酰胺）三嵌段共聚物胶束纳米颗粒

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Thermoresponsive poly(N-isopropyl acrylamide) (PNIPAM)-block-hydroxy-terminated polybutadine-block-PNIPAM triblock copolymers were synthesized by atom transfer radical polymerization; this was followed by the in situ epoxidation reaction of peracetic acid. The copolymers were characterized by H-1-NMR, Fourier transform infrared spectroscopy, and size exclusion chromatography measurements, and their physicochemical properties in aqueous solution were investigated by surface tension measurement, fluorescent spectrometry, ultraviolet-visible transmittance, transmission electron microscopy observations, dynamic light scattering, and so on. The experimental results indicate that the epoxidized copolymer micelle aggregates retained a spherical core-shell micelle structure similar to the control sample. However, they possessed a decreased critical aggregate concentration (CAC), increased hydrodynamic diameters, and a high aggregation number and cloud point because of the incorporation of epoxy groups and so on. In particular, the epoxidized copolymer micelles assumed an improved loading capacity and entrapment efficiency of the drug, a preferable drug-release profiles without an initial burst release, and a low cytotoxicity. Therefore, they were more suitable for the loading and delivery of the hydrophobic drug as a controlled release drug carrier. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41877.
机译：通过原子转移自由基聚合反应合成了热敏性聚（N-异丙基丙烯酰胺）-嵌段-羟基-端基的聚丁二烯-嵌段-PNIPAM三嵌段共聚物。随后是过氧乙酸的原位环氧化反应。通过H-1-NMR，傅里叶变换红外光谱和尺寸排阻色谱法对共聚物进行了表征，并通过表面张力测量，荧光光谱，紫外可见透射率，透射电子显微镜观察，动态研究了它们在水溶液中的理化性质。光散射等。实验结果表明，环氧化共聚物胶束聚集体保留了类似于对照样品的球形核-壳胶束结构。但是，由于引入了环氧基团等，它们的临界聚集体浓度（CAC）降低，流体动力学直径增大，聚集数和浊点高。特别地，环氧化共聚物胶束假定了药物的提高的负载能力和包封效率，没有初始突释的优选的药物释放曲线以及低的细胞毒性。因此，它们更适合作为控制释放药物载体的疏水性药物的负载和递送。 （c）2015 Wiley Periodicals，Inc. J. Appl。 Polym。科学2015，132，41877。

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