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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Computer aided design optimisation of microfluidic flow distributors
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Computer aided design optimisation of microfluidic flow distributors

机译：微流分配器的计算机辅助设计优化

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This study reports on a quantitative study of the influence of the most important geometrical design parameters for micro-machined flow distributors with uniform cross-section and filled with diamond-shaped pillars having their longest dimension oriented perpendicular to the axial flow direction. It was found that the shape of the bands eluting from the distributor improves with increasing aspect ratio (AR) of the pillars, both in terms of global warp and local axial dispersion. Increasing the AR from 5 to 25 reduces the distributor length needed to bring the maximal transversal velocity difference below 5% from 170 μm to 15 μm when using pillars with axial width of 5 μm. To solve the problem that high AR pillar distributors only have a limited number of exit points, and therefore produce bands with a strong local warp, one can conceive mixed size distributors, wherein a zone filled with several rows of very high AR pillars is followed by one or more zones consisting of pillars with a smaller AR. With such a design, the variance of the eluting bands can be reduced to only 30% of the variance of a single size distributor.
机译：这项研究报告了对最重要的几何设计参数对具有均匀横截面并装有最长尺寸垂直于轴向流动方向的菱形柱的微型机械流量分配器的影响的定量研究。已经发现，就整体翘曲和局部轴向分散而言，随着分布柱的长宽比（AR）的增加，从分配器洗脱的带的形状会改善。当使用轴向宽度为5μm的立柱时，将AR从5增加到25会减少使最大横向速度差从170μm到15μm低于5％所需的分配器长度。为了解决高AR立柱分配器仅具有有限数量的出口点，并因此产生具有强烈局部翘曲的带的问题，可以构想出混合尺寸的分布器，其中填充有几行非常高的AR立柱的区域后面是一个或多个区域，这些区域由具有较小AR的支柱组成。通过这种设计，洗脱带的方差可以减少到单个大小分配器方差的30％。

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