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首页> 外文期刊>Journal of chromatography, A: Including electrophoresis and other separation methods >Benefits and pitfalls of the application of screening methods for the analysis of pesticide residues in fruits and vegetables
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Benefits and pitfalls of the application of screening methods for the analysis of pesticide residues in fruits and vegetables

机译：应用筛选方法分析水果和蔬菜中农药残留的好处和陷阱

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摘要

The goal of this study was to expand knowledge on the performance of screening methods based on accurate mass measurements using a liquid chromatography electrospray quadrupole time-of-flight mass spectrometry (LC-ESI-QTOF-MS) system operating in full scan mode and with automatic identification based on the use accurate-mass databases. The study involved the analysis of 97 pesticides, in five matrices (tomato, pepper, zucchini, orange and leek) and at three concentration levels (20, 50 and 100μgkg~(-1)). Aspects concerning optimization of the search parameters, sensitivity, matrix effects, efficiency of the algorithm search, usefulness of fragment ions, etc., are evaluated in deep. Sensitivity requirements have been identified as the main obstacle affecting the automatic identification of pesticides, especially in complex matrices, where the ionization suppression reduces the detectability of analytes. In addition, we have detected some failures in the software used for automatic data processing in terms of analysis of isobaric compounds, use of isotopic clusters, spectral deconvolution and data processing speed that hamper the correct identification in some pesticide/matrix combinations. These drawbacks should be improved in the future for its effective implementation in routine residue analysis.
机译：这项研究的目的是扩展知识的筛查方法的性能，该方法基于使用在全扫描模式下运行的液相色谱电喷雾四极杆飞行时间质谱（LC-ESI-QTOF-MS）系统进行准确的质量测量基于使用精确质量数据库的自动识别。该研究涉及5种基质（番茄，辣椒，西葫芦，橙子和韭菜）中三种浓度水平（20、50和100μgkg〜（-1））中的97种农药的分析。对搜索参数的优化，灵敏度，矩阵效应，算法搜索的效率，碎片离子的有效性等方面进行了深入评估。灵敏度要求已被确定为影响农药自动识别的主要障碍，尤其是在复杂基质中，电离抑制降低了分析物的可检测性。此外，我们在等压化合物的分析，同位素簇的使用，光谱解卷积和数据处理速度方面检测到用于自动数据处理的软件中的某些故障，这些故障妨碍了某些农药/基质组合的正确识别。为了在常规残留分析中有效实施，这些缺点应在将来得到改善。

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