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首页> 外文期刊>Current drug targets. CNS and neurological disorders >Exploring genetic influences on cognition: emerging strategies for target validation and treatment optimization.
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Exploring genetic influences on cognition: emerging strategies for target validation and treatment optimization.

机译：探索遗传对认知的影响：目标验证和治疗优化的新兴策略。

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摘要

Genomic research has produced an abundance of new candidate targets that remain to be validated as potential treatments for neuropsychiatric disorders. Functional neuroimaging, meanwhile, has provided detailed new insights into the neural circuits involved in emotional and cognitive control. At the growing interface between these independent lines of progress, new efforts are underway to unify our understanding of regional brain function with that of genetic and biochemical influences on behavior. Such a unified understanding of the mechanisms involved in cognitive and emotional control may open up new avenues for therapeutic intervention at the pharmacological and behavioral levels. In line with this, a new initiative sponsored by the National Institutes of Mental Health (NIMH) aims to bridge gaps between clinical diagnostics and the molecular processes that influence susceptibility to psychiatric disorders. A major goal of this initiative is to identify the neural and neurochemical substrates of basic cognitive processes that are disrupted in psychiatric disorders and to examine the influence of genetic factors at the cognitive level. This review describes some well-known findings that are at the forefront of this interface. The progress already made indicates that the goals of the new initiative are well founded and achievable.
机译：基因组研究已经产生了大量新的候选靶标，仍有待验证作为神经精神疾病的潜在治疗方法。同时，功能性神经影像学对涉及情绪和认知控制的神经回路提供了详细的新见解。在这些独立的进步路线之间日益紧密的联系上，正在进行新的努力，以使我们对区域脑功能的理解与遗传和生化对行为的影响相统一。对认知和情绪控制中涉及的机制的这种统一理解，可以为药理和行为层面的治疗干预开辟新途径。与此相应，美国国家心理健康研究所（NIMH）发起的一项新计划旨在弥合临床诊断与影响精神疾病易感性的分子过程之间的差距。该计划的主要目标是确定在精神疾病中被破坏的基本认知过程的神经和神经化学底物，并在认知水平上检查遗传因素的影响。这篇评论描述了一些最著名的发现，这些发现位于该界面的最前沿。已经取得的进展表明，新倡议的目标是有充分根据和可实现的。

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