• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >MicroRNAs and HIV-1 infection: Antiviral activities and beyond
【24h】

MicroRNAs and HIV-1 infection: Antiviral activities and beyond

机译：MicroRNA和HIV-1感染：抗病毒活性及其他

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Cellular microRNAs (miRNAs) are an important class of small, non-coding RNAs that bind to host mRNAs based on sequence complementarity and regulate protein expression. They play important roles in controlling key cellular processes including cellular inception, differentiation and death. While several viruses have been shown to encode for viral miRNAs, controversy persists over the expression of a functional miRNA encoded in the human immunodeficiency virus type 1 (HIV-1) genome. However, it has been reported that HIV-1 infectivity is influenced by cellular miRNAs. Either through directly targeting the viral genome or by targeting host cellular proteins required for successful virus replication, multiple cellular miRNAs seem to modulate HIV-1 infection and replication. Perhaps as a survival strategy, HIV-1 may modulate proteins in the miRNA biogenesis pathway to subvert miRNA-induced antiviral effects. Global expression profiles of cellular miRNAs have also identified alterations of specific miRNAs post-HIV-1 infection both in vitro and in vivo (in various infected patient cohorts), suggesting potential roles for miRNAs in pathogenesis and disease progression. However, little attention has been devoted in understanding the roles played by these miRNAs at a cellular level. In this manuscript, we review past and current findings pertaining to the field of miRNA and HIV-1 interplay. In addition, we suggest strategies to exploit miRNAs therapeutically for curbing HIV-1 infectivity, replication and latency since they hold an untapped potential that deserves further investigation.
机译：细胞微RNA（miRNA）是一类重要的小型非编码RNA，它们基于序列互补性与宿主mRNA结合并调节蛋白质表达。它们在控制关键细胞过程（包括细胞起始，分化和死亡）中起着重要作用。尽管已经显示出几种病毒可编码病毒miRNA，但关于在人类1型免疫缺陷病毒（HIV-1）基因组中编码的功能性miRNA的表达仍存在争议。但是，据报道HIV-1感染性受细胞miRNA的影响。通过直接靶向病毒基因组或靶向成功复制病毒所需的宿主细胞蛋白，多种细胞miRNA似乎可以调节HIV-1的感染和复制。也许作为一种生存策略，HIV-1可能会调节miRNA生物发生途径中的蛋白质，从而破坏miRNA诱导的抗病毒作用。细胞miRNA的整体表达谱也已经鉴定了HIV-1感染后特定的miRNA的体内外变化（在各种感染患者队列中），表明miRNA在发病机理和疾病进展中的潜在作用。但是，在细胞水平上，人们很少关注这些miRNA的作用。在本手稿中，我们回顾了与miRNA和HIV-1相互作用领域有关的过去和当前发现。此外，我们建议治疗性地利用miRNA抑制HIV-1感染性，复制和潜伏期的策略，因为它们具有尚未开发的潜力，值得进一步研究。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号