• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Journal of Molecular Biology >The human specialized DNA polymerases and non-B DNA: Vital relationships to preserve genome integrity
【24h】

The human specialized DNA polymerases and non-B DNA: Vital relationships to preserve genome integrity

机译：人类专用DNA聚合酶和非B DNA：维持基因组完整性的重要关系

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

In addition to the canonical right-handed double helix, DNA molecule can adopt several other non-B DNA structures. Readily formed in the genome at specific DNA repetitive sequences, these secondary conformations present a distinctive challenge for progression of DNA replication forks. Impeding normal DNA synthesis, cruciforms, hairpins, H DNA, Z DNA and G4 DNA considerably impact the genome stability and in some instances play a causal role in disease development. Along with previously discovered dedicated DNA helicases, the specialized DNA polymerases emerge as major actors performing DNA synthesis through these distorted impediments. In their new role, they are facilitating DNA synthesis on replication stalling sites formed by non-B DNA structures and thereby helping the completion of DNA replication, a process otherwise crucial for preserving genome integrity and concluding normal cell division. This review summarizes the evidence gathered describing the function of specialized DNA polymerases in replicating DNA through non-B DNA structures.
机译：除了规范的右手双螺旋结构外，DNA分子还可以采用其他几种非B DNA结构。这些二级构象易于在基因组中形成特定的DNA重复序列，对DNA复制叉的发展提出了独特的挑战。十字形，发夹状，H DNA，Z DNA和G4 DNA阻碍了正常的DNA合成，大大影响了基因组的稳定性，并在某些情况下在疾病发展中起因果作用。随着以前发现的专用DNA解旋酶的出现，专用DNA聚合酶作为通过这些扭曲的障碍进行DNA合成的主要参与者而出现。在他们的新角色中，它们促进了由非B DNA结构形成的复制停滞位点上的DNA合成，从而帮助完成了DNA复制，这对于保持基因组完整性和完成正常的细胞分裂至关重要。这篇综述总结了收集的证据，描述了专门的DNA聚合酶在通过非B DNA结构复制DNA中的功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号