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首页> 外文期刊>Journal of Molecular Biology >Chromatin structure and replication origins: Determinants of chromosome replication and nuclear organization
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Chromatin structure and replication origins: Determinants of chromosome replication and nuclear organization

机译：染色质的结构和复制起源：染色体复制和核组织的决定因素

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The DNA replication program is, in part, determined by the epigenetic landscape that governs local chromosome architecture and directs chromosome duplication. Replication must coordinate with other biochemical processes occurring concomitantly on chromatin, such as transcription and remodeling, to insure accurate duplication of both genetic and epigenetic features and to preserve genomic stability. The importance of genome architecture and chromatin looping in coordinating cellular processes on chromatin is illustrated by two recent sets of discoveries. First, chromatin-associated proteins that are not part of the core replication machinery were shown to affect the timing of DNA replication. These chromatin-associated proteins could be working in concert, or perhaps in competition, with the transcriptional machinery and with chromatin modifiers to determine the spatial and temporal organization of replication initiation events. Second, epigenetic interactions are mediated by DNA sequences that determine chromosomal replication. In this review, we summarize recent findings and current models linking spatial and temporal regulation of the replication program with epigenetic signaling. We discuss these issues in the context of the genome's three-dimensional structure with an emphasis on events occurring during the initiation of DNA replication.
机译：DNA复制程序部分取决于表观遗传格局，该表观遗传格局支配本地染色体的结构并指导染色体的复制。复制必须与在染色质上同时发生的其他生化过程协调一致，例如转录和重塑，以确保遗传和表观遗传学特征的准确复制，并保持基因组稳定性。最近两套新发现说明了基因组结构和染色质环在协调染色质上细胞过程中的重要性。首先，染色质相关蛋白不是核心复制机制的一部分，它会影响DNA复制的时间。这些与染色质相关的蛋白可能与转录机制和染色质修饰剂协同作用，或者可能在竞争中共同作用，以确定复制起始事件的时空组织。其次，表观遗传相互作用是由决定染色体复制的DNA序列介导的。在这篇综述中，我们总结了最近的发现和将复制程序的时空调节与表观遗传信号联系起来的当前模型。我们在基因组的三维结构的背景下讨论这些问题，重点是在DNA复制起始过程中发生的事件。

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