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首页> 外文期刊>Journal of Neurophysiology >Mechanisms underlying long-interval cortical inhibition in the human motor cortex: A TMS-EEG study
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Mechanisms underlying long-interval cortical inhibition in the human motor cortex: A TMS-EEG study

机译：TMS-EEG研究人类运动皮层长间隔皮质抑制的机制

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Long-interval cortical inhibition (LICI) refers to suppression of neuronal activity following paired-pulse transcranial magnetic stimulation (TMS) with inter-stimulus intervals (ISIs) between 50 and 200 ms. LICI can be measured either from motor-evoked potentials (MEPs) in small hand muscles or directly from the cortex using concurrent electroencephalography (EEG). However, it remains unclear whether EEG inhibition reflects similar mechanisms to MEP inhibition. Eight healthy participants received single- and paired-pulse TMS (ISI = 100 ms) over the motor cortex. MEPs were measured from a small hand muscle (first dorsal interosseus), whereas early (P30, P60) and late (N100) TMS-evoked cortical potentials (TEPs) were measured over the motor cortex using EEG. Conditioning and test TMS intensities were altered, and modulation of LICI strength was measured using both methods. LICI of MEPs and both P30 and P60 TEPs increased in strength with increasing conditioning intensities and decreased with increasing test intensities. LICI of N100 TEPs remained unchanged across all conditions. In addition, MEP and P30 LICI strength correlated with the slope of the N100 evoked by the conditioning pulse. LICI of early and late TEP components was differentially modulated with altered TMS intensities, suggesting independent underlying mechanisms. LICI of P30 is consistent with inhibition of cortical excitation similar to MEPs, whereas LICI of N100 may reflect presynaptic autoinhibition of inhibitory interneurons. The N100 evoked by the conditioning pulse is consistent with the mechanism responsible for LICI, most likely GABAB-mediated inhibition of cortical activity. ? 2013 the American Physiological Society.
机译：长间隔皮层抑制（LICI）指的是在成对脉冲经颅磁刺激（TMS）之后，以50至200 ms之间的刺激间隔（ISIs）抑制神经元活动。 LICI既可以通过小手肌肉的运动诱发电位（MEP）进行测量，也可以使用同步脑电图（EEG）直接从皮质进行测量。然而，目前尚不清楚EEG抑制是否反映了与MEP抑制相似的机制。八名健康参与者在运动皮层上接受了单脉冲和成对脉冲TMS（ISI = 100 ms）。 MEPs是从小手肌肉（第一背骨间骨）测量的，而早期（P30，P60）和晚期（N100）的TMS诱发的皮质电位（TEPs）是通过脑电图测量的。调节条件和测试TMS强度，并使用这两种方法测量LICI强度的调制度。 MEP和P30和P60 TEP的LICI随强度的增加而增加，而随测试强度的增加而降低。 N100 TEP的LICI在所有条件下均保持不变。此外，MEP和P30 LICI强度与调节脉冲引起的N100的斜率相关。早期和晚期TEP成分的LICI受TMS强度变化的差异调节，表明存在独立的潜在机制。 P30的LICI与类似于MEP的皮质兴奋抑制作用一致，而N100的LICI可能反映突触前神经抑制性中间神经元的自抑制作用。调节脉冲诱发的N100与负责LICI（最可能是GABAB介导的皮质活性抑制）的机制一致。 ？ 2013年美国生理学会。

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