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首页> 外文期刊>Current drug abuse reviews. >Cardioprotection by regular ethanol consumption: potential mechanisms and clinical application.
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Cardioprotection by regular ethanol consumption: potential mechanisms and clinical application.

机译：经常食用乙醇对心脏的保护作用：潜在的机制和临床应用。

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Epidemiological studies demonstrate that excessive drinking is associated with hypertension, cerebral bleeding and loss of cardiac contractility. Conversely, studies have shown that mortality rates for people who regularly drink ethanol in moderation are lower than in abstainers, primarily due to decreased fatal ischemic heart disease. Further, moderate ethanol consumers have lower rates of myocardial infarction compared with abstainers. These beneficial cardiac effects may be due to pleiotropic effects of ethanol on lipids, platelets, and fibrinolytic activity. During the past decade, studies conducted in several animal models have revealed that light to moderate regular ethanol consumption renders hearts more tolerant to myocardial ischemia-reperfusion injury; to a degree similar to cardiac ischemic preconditioning (brief episodes of ischemia dramatically limit infarct size following prolonged ischemia). Recent clinical evidence suggests that light to moderate ethanol consumption in the year prior to myocardial infarction is associated with reduced mortality following myocardial infarction. These findings suggest that light to moderate ethanol consumption not only prevents myocardial infarction but also improves survival after myocardial infarction. Proposed mechanisms of cardioprotection by regular ethanol consumption include activation of adenosine A1 receptors, alpha(1)-adrenoceptors, protein kinase C-delta and epsilon, adenosine triphosphate-dependent potassium (K(ATP)) channels, nitric oxide synthase and reduced leukocyte-endothelial cell adhesive interactions. In this review, we focus on the recent progress in elucidating the endogenous myocyte signaling mediating cardioprotection by light to moderate ethanol consumption.
机译：流行病学研究表明，过量饮酒与高血压，脑出血和心脏收缩力下降有关。相反，研究表明，经常喝适量乙醇的人的死亡率要比戒酒者低，这主要是由于致命性缺血性心脏病的减少。此外，与戒酒者相比，中度饮酒者的心肌梗塞发生率更低。这些有益的心脏效应可能是由于乙醇对脂质，血小板和纤溶活性的多效性作用。在过去的十年中，在几种动物模型中进行的研究表明，轻度至中度定期饮酒可使心脏更耐受心肌缺血-再灌注损伤。达到与心脏缺血预处理相似的程度（短暂的缺血发作严重限制了长期缺血后的梗塞面积）。最新的临床证据表明，心肌梗死前一年中轻度至中度的乙醇消耗与心肌梗死后死亡率降低有关。这些发现表明，轻度至中度的乙醇消耗不仅可以预防心肌梗塞，而且可以改善心肌梗塞后的生存率。通过定期饮酒来保护心脏的机制包括激活腺苷A1受体，α（1）-肾上腺素受体，蛋白激酶C-δ和ε，三磷酸腺苷依赖性钾（K（ATP））通道，一氧化氮合酶和减少白细胞内皮细胞粘附相互作用。在这篇综述中，我们集中在阐明内源性肌细胞信号转导通过轻度至中度乙醇消耗介导的心脏保护中的最新进展。

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