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首页> 外文期刊>Current opinion in clinical nutrition and metabolic care >Advances in methods to evaluate gastrointestinal transport function.
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Advances in methods to evaluate gastrointestinal transport function.

机译：评估胃肠道运输功能的方法的进展。

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Malnutrition is a serious problem, and malabsorption of nutrients is believed to be partially responsible for its prevalence. A wide variety of innovative methods have been developed to study gastrointestinal transport function. Some of the first research into gastrointestinal function was conducted in the 1700's with animal and human models. Methodological advancements continue to allow scientists to innovatively assess gastrointestinal function in animal models, cellular preparations and clinical settings. For this update, the methods are divided into in vivo, ex vivo, isolated cells and membranes, and molecular biology approaches. The in vivo methods discussed include animal and human models to measure nutrient disappearance, catheterized animal models, models with isolated intestinal segments, and a new procedure for sampling luminal fluid from patients. The ex vivo approaches discussed obtain measurements with intact tissue, such as the everted sleeves method and Ussing chambers. The utility of novel cellular preparations, membrane fractionation procedures and various molecular biology techniques is included. Various aspects of these methods are evaluated to provide a detailed overview of recent methodological developments.
机译：营养不良是一个严重的问题，营养素吸收不良被认为是造成营养不良的部分原因。已经开发出多种创新方法来研究胃肠运输功能。关于胃肠功能的第一批研究是在1700年代用动物和人类模型进行的。方法学的进步继续使科学家能够创新地评估动物模型，细胞制剂和临床环境中的胃肠功能。对于此更新，方法分为体内，离体，分离的细胞和膜以及分子生物学方法。讨论的体内方法包括用于测量营养物质消失的动物和人类模型，带导管的动物模型，具有独立肠段的模型以及用于从患者体内采样腔液的新程序。讨论的离体方法可使用完整的组织进行测量，例如翻袖法和Ussing chambers。包括新型细胞制剂，膜分离程序和各种分子生物学技术的实用性。对这些方法的各个方面进行了评估，以提供有关最新方法学发展的详细概述。

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