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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p
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A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p

机译：ZFP609圆形RNA通过海绵MIR-194-5P调节肌细胞分化

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摘要

Skeletal muscle development and growth regulatory mechanism is the focus of both animal genetics and medicine. The recent studies indicate that covalently closed circular RNAs (circRNAs) also play important role on muscle development through sequestering specific miRNAs. The present study was conducted to determine the functional roles of circZfp609, a recently identified circRNA, in the regulation of myogenesis in mouse myoblast cell line (C2G12). circZfp609 is predicted to has binding sites of miR-194-5p. circZfp609 knockdown increased the expression of MyfS and MyoG, which indicated that circZfp609 suppressed myogenic differentiation. Via a luciferase screening assay, circZfp609 is observed to sponge to miR-194-5p with four potential binding sites. Specifically, we show that circZfp609 can sponge miR-194-5p to sequester its inhibition on BCLAF1 so as to repress the myogenic differentiation. Modulation of circZfp609 expression in muscle tissue may emerge as a potential target in breeding strategies attempting to control muscle development. (C) 2018 Published by Elsevier B.V.
机译：骨骼肌发展和成长监管机制是动物遗传和医学的重点。最近的研究表明，共价封闭的圆形RNA（CircrNA）通过螯合特异性miRNA也发挥着肌肉发育的重要作用。进行了本研究以确定在小鼠肌细胞线（C2G12）中肌细胞生成的调节中最近鉴定的CircrNA的CirczFP609的功能作用。 CirczFP609预计有MIR-194-5P的结合位点。 CirczFP609敲低增加了MyFS和Myog的表达，表明CirczFP609抑制了肌遗传学分化。通过荧光素酶筛选测定，观察​​到CirczFP609以四个潜在的结合位点海绵到miR-194-5p。具体而言，我们表明CirczFP609可以将miR-194-5p海绵螯合在Bclaf1上抑制，以抑制肌遗传学分化。肌肉组织中CirczFP609表达的调节可能是试图控制肌肉发育的育种策略中的潜在目标。 （c）2018由elestvier b.v出版。

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