[HNMP]HSO4 catalyzed synthesis of selenized polysaccharide and its immunomodulatory effect on RAW264.7 cells via MAPKs pathway

Li Rui; Qin Xiaojie; Liu Shuang; Zhang Xiaoyue; Zeng Xiaorong; Guo Hongyun; Wang Tao; Zhang Yongdong; Zhang Jinping; Zhang Ji; Wang Junlong

首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >[HNMP]HSO4 catalyzed synthesis of selenized polysaccharide and its immunomodulatory effect on RAW264.7 cells via MAPKs pathway

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[HNMP]HSO4 catalyzed synthesis of selenized polysaccharide and its immunomodulatory effect on RAW264.7 cells via MAPKs pathway

机译：[HNMP] HSO4催化通过Mapks途径对Raw264.7细胞的硒化多糖的合成及其免疫调节作用

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In this paper, selenized Artemisia sphaerocephala polysaccharides (SePAS) were obtained through employing N-methyl-2-pyrrolidone hydrosulfate as catalyst, which showed a maximum Se content enhanced to 8744 mu g/g, FT-IR, 1D/2D NMR, X-ray photoelectron spectroscopy (XPS) and size-exclusion chromatograph analysis exhibited that Se had been successfully introduced into PAS and existed in the form of selenate group (Se4+) with the substitution position at C-6. Furthermore, immunostimulating assays indicated that SePAS with high Se content exhibited stronger immunomodulatory activities by upregulated the phosphorylation level of ERK, JNK and p38, thus enhancing RAW264.7 cells proliferation, phagocytosis, levels of interleukin-6, nitric oxide, tumor necrosis factor and interleukin-1 beta. The current outcome suggested that Se content might be a critical factor affecting the immunomodulatory effects of selenized PAS on macrophage RAW264.7. (C) 2020 Elsevier B.V. All rights reserved.

机译：本文通过使用N-甲基-2-吡咯烷酮氢磺酸氢盐作为催化剂，获得了硒化蒿属植物磷哌菌菌多糖（SEPAS），其显示出最大SE含量增强至8744μg，FT-IR，1D / 2D NMR，X. -Ray光电子谱（XPS）和尺寸排除色谱仪分析表明，SE已成功地引入PAS并以硒酸盐基团（SE4 +）的形式存在于C-6的替代位置。此外，免疫刺激测定表明，具有高SE含量的SEPA通过上调ERK，JNK和P38的磷酸化水平而表现出更强的免疫调节活性，从而增强Raw264.7细胞增殖，吞噬作用，白细胞介素-6，一氧化氮，肿瘤坏死因子和白细胞介素-1β。目前的结果表明，SE含量可能是影响硒化PA对巨噬细胞Raw264.7的免疫调节作用的关键因素。（c）2020 Elsevier B.v.保留所有权利。

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来源
《International Journal of Biological Macromolecules: Structure, Function and Interactions》 |2020年第1期|共12页
作者
Li Rui; Qin Xiaojie; Liu Shuang; Zhang Xiaoyue; Zeng Xiaorong; Guo Hongyun; Wang Tao; Zhang Yongdong; Zhang Jinping; Zhang Ji; Wang Junlong;
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作者单位

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Gansu Acad Med Sci Lanzhou 730050 Peoples R China;

Gansu Acad Med Sci Lanzhou 730050 Peoples R China;

Gansu Acad Med Sci Lanzhou 730050 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

Northwest Normal Univ Coll Life Sci Anning Eastrd 967 Lanzhou 730070 Peoples R China;

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正文语种 eng
中图分类生物大分子的结构和功能;
关键词
Anemisia sphaerocephala polysaccharides; Selenylation; Immunomodulatory activity;

机译：嗜睡素孢子菌多糖;亚苯基化;免疫调节活动;

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1. [HNMP]HSO4 catalyzed synthesis of selenized polysaccharide and its immunomodulatory effect on RAW264.7 cells via MAPKs pathway [J] . Li Rui, Qin Xiaojie, Liu Shuang, International Journal of Biological Macromolecules: Structure, Function and Interactions . 2020,第1期

机译：[HNMP] HSO4催化通过Mapks途径对Raw264.7细胞的硒化多糖的合成及其免疫调节作用
2. Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways [J] . Mouna Achoui, Karen Heyninck, Chung Yeng Looi, Drug Design, Development and Therapy . 2014,第1期

机译：17-O-乙酰ac啶内酯对RAW264.7细胞和HUVEC的免疫调节作用：MAPK和NF-κB通路的参与
3. Immunostimulatory effects of the intracellular polysaccharides isolated from liquid culture of Ophiocordyceps sinensis (Ascomycetes) on RAW264.7 cells via the MAPK and PI3K/Akt signaling pathways [J] . Liu Yan, Li Qi-Zhang, Li Liu-Ding-Ji, Journal of Ethnopharmacology: An Interdisciplinary Journal Devoted to Bioscientific Research on Indigenous Drugs . 2021,第1期

机译：通过MAPK和PI3K / AKT信号通路在Raw264.7细胞上从Ophiocordyceps Sinensis（Ascomycetessis（Ascomycetes）液体培养中分离的细胞内多糖的免疫刺激作用
4. LANTHANUM SUPPRESSES TARGET GENE EXPRESSION VIA NF-KAPPA B PATHWAY IN raw264.7 CELLS [C] . Yang Wang, Fei Guo, Yuanlei Lou, 第四届国际后基因组生命科学技术学术论坛 . 2006

机译：镧通过raw264.7细胞中的NF-κB通路抑制靶基因表达
5. Synthesis and Evaluation of Biological Activity of a Potential Immunomodulatory Zwitterionic Polysaccharide. [D] . Basava, Vikram. 2016

机译：潜在的免疫调节两性离子多糖的合成和生物活性的评估。
6. Immunomodulatory effects of 17-O-acetylacuminolide in RAW264.7 cells and HUVECs: involvement of MAPK and NF-κB pathways [O] . Mouna Achoui, Karen Heyninck, Chung Yeng Looi, 2014

机译：17-O-乙酰ac基内酯对RAW264.7细胞和HUVEC的免疫调节作用：涉及MAPK和NF-κB途径
7. Immunomodulatory activity of Ganoderma lucidum immunomodulatory protein via PI3K/Akt and MAPK signaling pathways in macrophage RAW264.7 cells [O] . Xuanwei Zhou, Qizhang Li, Yuzhou Chang, 2018

机译：通过PI3K / AKT和MAPK信号通路在巨噬细胞RAW264.7细胞中通过PI3K / AKT和MAPK信号通路的免疫调节活性

[HNMP]HSO4 catalyzed synthesis of selenized polysaccharide and its immunomodulatory effect on RAW264.7 cells via MAPKs pathway

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