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首页> 外文期刊>International Journal of Biological Macromolecules: Structure, Function and Interactions >Characterization of ionic cross-linked composite foams with different blend ratios of alginate/pectin on the synergistic effects for wound dressing application
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Characterization of ionic cross-linked composite foams with different blend ratios of alginate/pectin on the synergistic effects for wound dressing application

机译：具有藻酸盐/果胶不同共混比的离子交联复合泡沫的表征在伤口敷料应用中的协同作用下

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摘要

Alginate and pectin have been widely employed together in various industrial and biomedical applications due to their synergistic interaction. Although alginate and pectin have been used as composite materials in films, gels, and particles, research characterizing their properties in foams is scarce. Thus, in the present study, we fabricated alginate-pectin composite foams with different blending ratios (9:1, 7:3, and 5:5) using calcium ion cross-linking and characterized their properties. It was found that the G' values of rehydrated alginate-pectin 9:1 foam was higher than those of the other rehydrated foams in the rheological behavior. In addition, higher pectin levels in the composite foams led to more water being absorbed during swelling tests and the higher release of BSA in drug-release testing. In indirect and direct cytotoxicity testing, none of the foams exhibited cell cytotoxicity for fibroblast and keratinocyte cells. These results suggest that controlling the pectin content in alginate-pectin foams is key to adjusting their mechanical properties, water absorption, and drug-release ability. In addition, alginate-pectin composite foams are promising candidates for use in wound-dressing applications. (C) 2019 Elsevier B.V. All rights reserved.
机译：由于其协同互动，在各种工业和生物医学应用中广泛使用藻酸盐和果胶。虽然藻酸盐和果胶已被用作薄膜，凝胶和颗粒中的复合材料，但表征其在泡沫中的性质的研究是稀缺的。因此，在本研究中，我们使用钙离子交联并表征其性质，用不同的混合比（9：1,7：3和5：5）制造了藻酸盐蛋白复合泡沫（9：1,7：3和5：5）。发现再水合藻酸盐蛋白的G'值9：1泡沫的流变行为中的其他再水合泡沫的值高。此外，复合泡沫中的较高果胶水平导致在溶胀试验期间吸收更多的水以及药物释放试验中的BSA的更高释放。在间接和直接的细胞毒性测试中，泡沫中没有泡沫表现出用于成纤维细胞和角质形成细胞的细胞毒性。这些结果表明，控制藻酸盐果胶泡沫中的果胶含量是调节其机械性能，吸水和药物释放能力的关键。此外，藻酸盐果胶复合泡沫是有希望用于卷绕应用的候选物。 （c）2019 Elsevier B.v.保留所有权利。

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